INT211132

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.71
Pain Relevance 2.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTX1)
MTX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 122 100.00 Very High Very High Very High
rheumatoid arthritis 219 99.98 Very High Very High Very High
Etanercept 15 99.84 Very High Very High Very High
psoriasis 14 98.76 Very High Very High Very High
cINOD 8 98.68 Very High Very High Very High
Arthritis 54 96.36 Very High Very High Very High
Adalimumab 258 95.48 Very High Very High Very High
Leflunomide 15 94.64 High High
Inflammation 27 90.16 High High
antagonist 47 82.64 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 266 99.98 Very High Very High Very High
Urinary Tract Infection 3 99.58 Very High Very High Very High
Psoriasis 16 98.76 Very High Very High Very High
INFLAMMATION 28 98.20 Very High Very High Very High
Disease Progression 14 98.08 Very High Very High Very High
Seronegative Spondarthritis 42 96.36 Very High Very High Very High
Arthritis 19 90.16 High High
Disease 86 85.00 Quite High
Anaphylaxis 4 48.04 Quite Low
Autoimmune Disease 10 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For MTX-naïve patients with rapidly progressive, early RA, adalimumab plus MTX showed greater radiographic efficacy than MTX monotherapy across the entire spectrum of radiographic disease progression parameters; moreover, combination therapy prevented nearly all severe radiographic progression observed with MTX alone, as early as 6 months (van der Heijde, Landewe, et al 2005).


Positive_regulation (observed) of Gene_expression (observed) of MTX associated with rheumatoid arthritis, adalimumab, methotrexate and disease progression
1) Confidence 0.23 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 1.08 Pain Relevance 1.11
Patients (n=313) were stratified according to MTX use (yes or no) and extent of psoriasis involvement (?
Positive_regulation (according) of Gene_expression (stratified) of MTX associated with psoriasis and methotrexate
2) Confidence 0.23 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936294 Disease Relevance 1.24 Pain Relevance 1.18
MTX therapy reduced p-STAT1 MFI values in CD20+ cells (p?
Positive_regulation (-) of Gene_expression (values) of MTX associated with methotrexate
3) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2724743 Disease Relevance 0 Pain Relevance 0.24
In this regard, the FCGR3B NA2 allele has been shown to be associated with urinary tract infections in patients with RA treated with MTX or etanercept.32 Fc?
Positive_regulation (treated) of Gene_expression (with) of MTX associated with rheumatoid arthritis, etanercept, methotrexate and urinary tract infection
4) Confidence 0.06 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.40 Pain Relevance 0.41

General Comments

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