INT211164

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.18
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf3) extracellular region (Csf3) enzyme binding (Csf3)
Anatomy Link Frequency
granulocyte 4
Csf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 5 98.44 Very High Very High Very High
rheumatoid arthritis 2 93.52 High High
Inflammation 13 91.72 High High
Inflammatory response 12 63.92 Quite High
vincristine 36 31.36 Quite Low
cytokine 5 18.40 Low Low
Central nervous system 18 5.00 Very Low Very Low Very Low
methotrexate 14 5.00 Very Low Very Low Very Low
monoamine 6 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 5 98.44 Very High Very High Very High
Neutropenia 2 96.36 Very High Very High Very High
Rheumatoid Arthritis 2 93.52 High High
Leukopenia 4 93.16 High High
Thrombocytopenia 4 92.40 High High
Arthropathy 1 92.32 High High
INFLAMMATION 27 91.72 High High
Lymphatic System Cancer 70 89.04 High High
Toxicity 18 89.00 High High
Disease 21 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, partial antagonism of endogenous G-CSF, as described in this study for LNA-antimiR-mediated G-CSF down-regulation, might provide a positive outcome for arthritis patients without increased risk of severe neutropenia.
Regulation (regulation) of Positive_regulation (mediated) of G-CSF associated with neutropenia and arthritis
1) Confidence 0.38 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 1.69 Pain Relevance 0.55
The findings indicated that, despite some increase in hemotoxicity, moderate dose escalation was safe for most patients receiving granulocyte colony-stimulating factor (G-CSF) and standard supportive treatment.
Regulation (safe) of Positive_regulation (receiving) of granulocyte colony-stimulating factor in granulocyte
2) Confidence 0.12 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936303 Disease Relevance 0.75 Pain Relevance 0
The findings indicated that, despite some increase in hemotoxicity, moderate dose escalation was safe for most patients receiving granulocyte colony-stimulating factor (G-CSF) and standard supportive treatment.
Regulation (safe) of Positive_regulation (receiving) of G-CSF in granulocyte
3) Confidence 0.12 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936303 Disease Relevance 0.75 Pain Relevance 0

General Comments

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