INT211192

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Context Info
Confidence 0.73
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.04
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ACR) DNA binding (ACR) protein complex (ACR)
Anatomy Link Frequency
joint 1
ACR (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 188 99.36 Very High Very High Very High
abatacept 310 98.80 Very High Very High Very High
imagery 45 97.60 Very High Very High Very High
Etanercept 123 93.20 High High
rheumatoid arthritis 316 79.36 Quite High
Arthritis 86 78.00 Quite High
Multiple sclerosis 2 74.08 Quite High
Central nervous system 2 69.12 Quite High
Infliximab 24 52.08 Quite High
Inflammation 57 51.60 Quite High
Disease Link Frequency Relevance Heat
Disease 178 95.88 Very High Very High Very High
Arthritis 64 85.12 High High
Rheumatoid Arthritis 324 79.36 Quite High
Seronegative Spondarthritis 1 78.00 Quite High
Demyelinating Disease 6 74.08 Quite High
Pancytopenia 2 65.84 Quite High
Heart Rate Under Development 11 62.52 Quite High
Mycobacterial Infection 32 58.40 Quite High
Toxicity 8 52.76 Quite High
INFLAMMATION 68 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This trend was similar in both ACR50 and ACR70 response.
Localization (response) of ACR
1) Confidence 0.73 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2779400 Disease Relevance 0.65 Pain Relevance 0.42
This trend was similar in both ACR50 and ACR70 response.
Localization (response) of ACR
2) Confidence 0.73 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2779400 Disease Relevance 0.64 Pain Relevance 0.42
At week 52, patients allocated to treatment with tocilizumab achieved an ACR20, ACR50, and ACR70 response of 78%, 64%, and 44% in contrast to 34%, 13%, and 6% in the DMARD group, respectively.
Localization (response) of ACR70
3) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.25 Pain Relevance 0.10
At week 52, patients allocated to treatment with tocilizumab achieved an ACR20, ACR50, and ACR70 response of 78%, 64%, and 44% in contrast to 34%, 13%, and 6% in the DMARD group, respectively.
Localization (response) of ACR50
4) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.30 Pain Relevance 0.13
At week 52, patients allocated to treatment with tocilizumab achieved an ACR20, ACR50, and ACR70 response of 78%, 64%, and 44% in contrast to 34%, 13%, and 6% in the DMARD group, respectively.
Localization (response) of ACR20
5) Confidence 0.42 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.30 Pain Relevance 0.13
Patients who had an ACR response on placebo and methotrexate did not show the same retardation of structural change as patients on abatacept and placebo.


Localization (response) of ACR associated with abatacept and methotrexate
6) Confidence 0.12 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936358 Disease Relevance 0.15 Pain Relevance 0.42
Similarly, ACR50 and ACR70 response rates were significantly higher in abatacept-treated patients (Fig. 3).
Localization (rates) of ACR50 associated with abatacept
7) Confidence 0.08 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.13 Pain Relevance 0.60
Similarly, ACR50 and ACR70 response rates were significantly higher in abatacept-treated patients (Fig. 3).
Localization (rates) of ACR70 associated with abatacept
8) Confidence 0.08 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012435 Disease Relevance 0.13 Pain Relevance 0.59
Thus, surface imaging could improve the reliability of the active or swollen joint counts, which would lead to an overall improvement in the reliability of the ACR 20 and ACR 30.
Localization (reliability) of ACR 20 in joint associated with imagery
9) Confidence 0.06 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374475 Disease Relevance 0.48 Pain Relevance 0.23

General Comments

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