INT211211

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.36
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Egfr) cell morphogenesis (Egfr) Golgi apparatus (Egfr)
endoplasmic reticulum (Egfr) intracellular (Egfr) enzyme binding (Egfr)
Anatomy Link Frequency
skin 2
Egfr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 99.16 Very High Very High Very High
addiction 4 59.40 Quite High
metalloproteinase 2 45.12 Quite Low
corticosteroid 1 5.28 Low Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Solid Tumor 10 99.84 Very High Very High Very High
INFLAMMATION 1 99.16 Very High Very High Very High
Pancreatic Cancer 114 98.92 Very High Very High Very High
Exanthema 58 88.24 High High
Cancer 56 70.44 Quite High
Infection 3 67.44 Quite High
Pruritus 2 66.44 Quite High
Colon Cancer 6 47.28 Quite Low
Erythema 1 46.68 Quite Low
Malignant Neoplastic Disease 13 34.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This article will review the molecular mechanism of EGFR inhibition as a therapeutic approach in solid tumors; the preclinical data supporting EGFR inhibition in solid tumors including pancreatic cancer; and finally, the clinical trials that have established the small molecule TKI erlotinib as an approved therapy for advanced pancreatic cancer.


Positive_regulation (supporting) of Negative_regulation (inhibition) of EGFR associated with pancreatic cancer and solid tumor
1) Confidence 0.50 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727779 Disease Relevance 0.78 Pain Relevance 0
Alternatively, EGFR inhibition may induce a local or systemic inflammatory skin reaction (Perez-Soler and Saltz 2005).
Spec (may) Positive_regulation (induce) of Negative_regulation (inhibition) of EGFR in skin associated with inflammation
2) Confidence 0.46 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936363 Disease Relevance 0.58 Pain Relevance 0.08

General Comments

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