INT211265

Context Info Confidence 0.04 First Reported 2007 Last Reported 2007 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.26 Pain Relevance 0.14

mitochondrion (Hk2) carbohydrate metabolic process (Hk2) kinase activity (Hk2)

Anatomy Link Frequency blood 2 liver parenchyma 2 Hk2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat imagery 51 89.44 palliative 3 5.00

Disease Link Frequency Relevance Heat Hepatocellular Cancer 24 100.00 Malignant Neoplastic Disease 27 99.78 Disease 27 98.00 Cholangiocarcinoma 12 92.80 Metastasis 36 92.52 Colon Cancer 9 90.56 Liver Cancer 6 89.36 Pancreatic Cancer 3 74.72 Cancer 51 73.36 Carcinoma 3 67.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

On the other hand, HK-II expression in high grade hepatocellular carcinoma (HCC) is elevated likely a result of upregulation caused by low levels of Glut-1 on the cell surface.

Spec (likely) Positive_regulation (elevated) of Gene_expression (expression) of HK-II associated with hepatocellular cancer

1) Confidence 0.04 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1939707 Disease Relevance 1.07 Pain Relevance 0.04

The value of PET/CT has been questioned for detection of intrahepatic disease because of the high background activity in the liver parenchyma due to high glucose metabolism and abundant expression of Glut-1 and hexokinase II (HK-II).

Positive_regulation (abundant) of Gene_expression (expression) of HK-II in liver parenchyma associated with disease

2) Confidence 0.03 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1939707 Disease Relevance 0.81 Pain Relevance 0.08

This suggests that it is the retention of FDG in malignant cells (as determined by Glut-1 and HK-II expression) rather than clearance of blood pool activity that is the most important factor in delayed lesion detection.

Positive_regulation (determined) of Spec (determined) Gene_expression (expression) of HK-II in blood associated with malignant neoplastic disease

3) Confidence 0.03 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1939707 Disease Relevance 0.37 Pain Relevance 0.03

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