INT211265

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.26
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hk2) carbohydrate metabolic process (Hk2) kinase activity (Hk2)
Anatomy Link Frequency
blood 2
liver parenchyma 2
Hk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 51 89.44 High High
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 24 100.00 Very High Very High Very High
Malignant Neoplastic Disease 27 99.78 Very High Very High Very High
Disease 27 98.00 Very High Very High Very High
Cholangiocarcinoma 12 92.80 High High
Metastasis 36 92.52 High High
Colon Cancer 9 90.56 High High
Liver Cancer 6 89.36 High High
Pancreatic Cancer 3 74.72 Quite High
Cancer 51 73.36 Quite High
Carcinoma 3 67.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, HK-II expression in high grade hepatocellular carcinoma (HCC) is elevated likely a result of upregulation caused by low levels of Glut-1 on the cell surface.
Spec (likely) Positive_regulation (elevated) of Gene_expression (expression) of HK-II associated with hepatocellular cancer
1) Confidence 0.04 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1939707 Disease Relevance 1.07 Pain Relevance 0.04
The value of PET/CT has been questioned for detection of intrahepatic disease because of the high background activity in the liver parenchyma due to high glucose metabolism and abundant expression of Glut-1 and hexokinase II (HK-II).
Positive_regulation (abundant) of Gene_expression (expression) of HK-II in liver parenchyma associated with disease
2) Confidence 0.03 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1939707 Disease Relevance 0.81 Pain Relevance 0.08
This suggests that it is the retention of FDG in malignant cells (as determined by Glut-1 and HK-II expression) rather than clearance of blood pool activity that is the most important factor in delayed lesion detection.
Positive_regulation (determined) of Spec (determined) Gene_expression (expression) of HK-II in blood associated with malignant neoplastic disease
3) Confidence 0.03 Published 2007 Journal Int Semin Surg Oncol Section Body Doc Link PMC1939707 Disease Relevance 0.37 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox