INT211272

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.79
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Igh-VS107 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 76 86.36 High High
headache 33 84.12 Quite High
Migraine 59 83.60 Quite High
corticosteroid 53 83.44 Quite High
metalloproteinase 2 75.12 Quite High
Multiple sclerosis 8 71.44 Quite High
cva 14 69.04 Quite High
Central nervous system 14 66.08 Quite High
Inflammatory marker 4 62.72 Quite High
fibrosis 24 49.68 Quite Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 3 99.80 Very High Very High Very High
Pancreatitis 260 99.54 Very High Very High Very High
Anti-phospholipid Antibody Syndrome 2 98.82 Very High Very High Very High
Stroke 20 97.98 Very High Very High Very High
Aging 5 97.28 Very High Very High Very High
Infection 111 96.88 Very High Very High Very High
Disease 124 95.32 Very High Very High Very High
Targeted Disruption 27 95.20 Very High Very High Very High
Purpura 5 88.20 High High
Adverse Drug Reaction 1 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured a 10–20 fold fluorescence increase for endogenous IgG in the treated compared to untreated regions and a ?
Positive_regulation (increase) of IgG
1) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.79 Pain Relevance 0.03
The longevity of bovine IgG in mice, as seen with day 7 prophylaxes, may be attributed to the function of neonatal Fc receptors (FcRn) which prevent circulating IgG from degradation by transporting it within and across cells [26], although this effect is much less pronounced with IgG delivered intranasally [25].
Positive_regulation (circulating) of IgG associated with aging
2) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964324 Disease Relevance 0.74 Pain Relevance 0
Sections were then washed in PBS, blocked for 1 h at RT (3% normal horse serum in PBS), incubated for 16 h at 4°C with mouse monoclonal TP25.99 or Q1/28 IgG [34,35] kindly provided by S.
Positive_regulation (incubated) of IgG
3) Confidence 0.04 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
IgG becomes elevated after 9–10 days and persists at detectable levels for life.
Positive_regulation (elevated) of IgG
4) Confidence 0.03 Published 2009 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2713854 Disease Relevance 1.06 Pain Relevance 0
All vaccines induced a significant increase in specific IgG compared to control by 14 days after the primary vaccine administration (Table 1).
Positive_regulation (increase) of IgG
5) Confidence 0.02 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.16 Pain Relevance 0
In the stroke patient with an antiphospholipid syndrome, the diagnosis was suspected on the basis of clinical and increased anticardiolipin IgG and lupus anticoagulant.
Positive_regulation (increased) of IgG associated with stroke, anti-phospholipid antibody syndrome and systemic lupus erythematosus
6) Confidence 0.02 Published 2007 Journal BMC Med Section Body Doc Link PMC1939710 Disease Relevance 0.97 Pain Relevance 0.36
One other patient had an elevated IgG level, but normal IgG4 level [12], and one patient did not have any laboratory work reported [13].
Positive_regulation (elevated) of IgG
7) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.04 Pain Relevance 0.15
The only patient with an elevated IgG4 was the patient who did not meet diagnostic criteria for AIP [14]; she also had an elevated total IgG level.
Positive_regulation (elevated) of IgG associated with pancreatitis
8) Confidence 0.02 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.03 Pain Relevance 0.15

General Comments

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