INT211294

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.89
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
hilus 1
synovial joints 1
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 73 99.80 Very High Very High Very High
Hippocampus 105 99.48 Very High Very High Very High
rheumatoid arthritis 13 97.52 Very High Very High Very High
GABAergic 3 86.00 High High
cerebral cortex 3 82.40 Quite High
Central nervous system 21 63.20 Quite High
Spinal cord 6 60.48 Quite High
Multiple sclerosis 6 57.84 Quite High
Inflammatory response 2 47.40 Quite Low
cytokine 39 5.28 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 50 99.48 Very High Very High Very High
Metastasis 50 97.56 Very High Very High Very High
Rheumatoid Arthritis 13 97.52 Very High Very High Very High
Apoptosis 96 95.16 Very High Very High Very High
Adhesions 71 92.68 High High
Carcinoma 50 90.52 High High
Convulsion 132 90.48 High High
Status Epilepticus 57 90.04 High High
Neurodegenerative Disease 36 75.76 Quite High
Death 27 74.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes including cellular migration, survival, and apoptosis [14]–[16].
CXCL12 Binding (binds) of associated with apoptosis
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.77 Pain Relevance 0.05
CXCL12 signaling via its primary receptor, CXCR4, guides migrating granule neural precursors from the hilus into the DG during development [15], [16].
CXCL12 Binding (receptor) of in hilus
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.40 Pain Relevance 0.42
Recently CXCL12 has been shown to bind the chemokine receptor CXCR7 [26].
CXCL12 Binding (bind) of associated with chemokine
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.34 Pain Relevance 0.18
In vitro treatment with CXCL12 did not increase phospho-histone H3 levels or alter nestin or ?
CXCL12 Binding (treatment) of
4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.28 Pain Relevance 0.14
To further investigate CXCL12-mediated guidance mechanisms, we next examined expression of CXCR4 and CXCR7, the two receptors that bind CXCL12 [39].
CXCL12 Spec (examined) Binding (bind) of
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.09
Migration of PBLs could be further enhanced by the addition of CXCL-10, CCL5, or CXCL-12 to the lower chamber, chemokines known to be up-regulated in RA synovial joints (Figure 6C).29 Subset analysis revealed enhanced migration of TCR?
CXCL-12 Binding (addition) of in synovial joints associated with chemokine and rheumatoid arthritis
6) Confidence 0.17 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.17

General Comments

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