INT211296

Context Info Confidence 0.13 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.31

Anatomy Link Frequency synovial joints 2 Trav6-3 (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 13 98.86 chemokine 5 98.24 cytokine 40 86.08 Inflammation 26 65.64 Inflammatory response 3 41.08 Multiple sclerosis 5 11.60 Neuritis 24 5.00 Peripheral nervous system 5 5.00 Arthritis 4 5.00 methotrexate 1 5.00

Disease Link Frequency Relevance Heat Rheumatoid Arthritis 13 98.86 Autoimmune Disease 9 95.00 INFLAMMATION 29 65.64 Targeted Disruption 19 63.08 Syndrome 19 50.00 Disorder Of Lipid Metabolism 6 50.00 Disease 20 37.28 Multiple Sclerosis 6 11.60 Experimental Autoimmune Neuritis 24 5.00 Cytomegalovirus Infection 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Migration of PBLs could be further enhanced by the addition of CXCL-10, CCL5, or CXCL-12 to the lower chamber, chemokines known to be up-regulated in RA synovial joints (Figure 6C).29 Subset analysis revealed enhanced migration of TCR?

Positive_regulation (enhanced) of TCR Binding (migration) of in synovial joints associated with chemokine and rheumatoid arthritis

1) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.10 Pain Relevance 0.21

Upon TCR ligation, they respond rapidly to secrete high levels of IFN-?

Positive_regulation (respond) of TCR Binding (ligation) of

2) Confidence 0.10 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2825561 Disease Relevance 0.22 Pain Relevance 0.10

General Comments

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