INT211299

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd3e) signal transducer activity (Cd3e)
Anatomy Link Frequency
T cells 2
Cd3e (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 13 79.68 Quite High
Inflammation 51 66.56 Quite High
cytokine 76 51.12 Quite High
chemokine 4 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Adalimumab 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 84.72 Quite High
Mycobacterial Infection 1 84.00 Quite High
Autoimmune Disease 2 81.92 Quite High
Rheumatoid Arthritis 13 79.68 Quite High
Systemic Lupus Erythematosus 1 77.68 Quite High
Solid Tumor 1 74.72 Quite High
Hematologic Neoplasms 1 73.44 Quite High
Cancer 67 67.28 Quite High
INFLAMMATION 43 66.56 Quite High
Inflammatory Bowel Disease 18 50.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The events leading to the down-regulation of TCR/CD3 complex expression on serial ligation by peptide/MHC complexes are well documented.12 Less well understood are the molecular mechanisms for the sustained down-regulation of TCR?
Regulation (regulation) of Gene_expression (expression) of CD3
1) Confidence 0.23 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.56 Pain Relevance 0.04
Although the populations of both NK (NK1.1+/CD3?)
Regulation (Although) of Gene_expression (populations) of CD3
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938346 Disease Relevance 0.12 Pain Relevance 0
The strong down-regulation of CD25 expression of CD3-activated T cells by Gal-4 proves the biological consequence of the Gal-4 binding to the CD3 complex.
Regulation (regulation) of Gene_expression (expression) of CD3 in T cells
3) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440804 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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