INT21130

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Context Info
Confidence 0.27
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.88
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 22 99.96 Very High Very High Very High
anticonvulsant 1 99.60 Very High Very High Very High
gABA 149 98.20 Very High Very High Very High
agonist 20 97.80 Very High Very High Very High
GABA receptor 4 97.60 Very High Very High Very High
Action potential 6 97.12 Very High Very High Very High
Neurotransmitter 3 93.84 High High
Sciatic nerve 2 86.04 High High
unmyelinated 38 83.72 Quite High
GABAergic 143 81.52 Quite High
Disease Link Frequency Relevance Heat
Myoclonus 17 98.12 Very High Very High Very High
Convulsion 1 92.24 High High
Nociception 8 83.20 Quite High
Lifespan 54 75.64 Quite High
Aging 34 67.08 Quite High
Epilepsy 1 65.24 Quite High
Anxiety Disorder 2 60.24 Quite High
Attention Deficit Hyperactivity Disorder 14 59.16 Quite High
Cerebral Hypoxia 1 45.80 Quite Low
Ganglion Cysts 13 43.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of GABAA receptors may therefore promote or antagonize myoclonus depending on which GABA receptors are involved, the state of the system, etc.
Positive_regulation (Stimulation) of GABAA associated with myoclonus and gaba receptor
1) Confidence 0.27 Published 1990 Journal FASEB J. Section Abstract Doc Link 2165012 Disease Relevance 1.24 Pain Relevance 0.59
Functionally, the activation of axonal GABAA receptors has been associated with a reduction in the safety factor of action potential initiation [19] and conduction [46] as well as the regulation of neurotransmitter release [47].
Positive_regulation (activation) of GABAA associated with action potential and neurotransmitter
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.28 Pain Relevance 0.92
As shown in Figure 1, in a representative injected site within the dlPFC, the variability of simple RTs dramatically increased after GABAA antagonist injection (Figure 1A), but not after GABAA agonist injection (Figure 1B).
Neg (not) Positive_regulation (increased) of GABAA associated with antagonist and agonist
3) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668174 Disease Relevance 0.11 Pain Relevance 0.30
In addition, there was a high level of GABAA?
Positive_regulation (level) of GABAA
4) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.05 Pain Relevance 0.17
3) to more of the mature (GABAA?
Positive_regulation (mature) of GABAA
5) Confidence 0.11 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.20 Pain Relevance 0.22

General Comments

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