INT211306

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Context Info
Confidence 0.21
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.79
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
145-2C11 1
B-cell 1
thymocytes 1
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 9 96.16 Very High Very High Very High
rheumatoid arthritis 49 90.72 High High
Infliximab 27 77.52 Quite High
cytokine 93 74.08 Quite High
methotrexate 6 73.76 Quite High
Inflammation 64 59.84 Quite High
Rheumatism 3 40.96 Quite Low
Arthritis 16 20.36 Low Low
cINOD 3 10.48 Low Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 10 96.92 Very High Very High Very High
Systemic Lupus Erythematosus 58 96.56 Very High Very High Very High
INFLAMMATION 73 95.80 Very High Very High Very High
Rheumatoid Arthritis 49 90.72 High High
Disease 68 89.28 High High
Cancer 19 88.40 High High
Necrosis 16 87.92 High High
Lymphopenia 5 82.56 Quite High
Death 9 81.96 Quite High
Autoimmune Disease 21 51.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression for both CD4 SP and CD8 SP thymocytes, and decreased frequency of post-positive selection TCR?
Localization (selection) of TCR in thymocytes
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.16 Pain Relevance 0
Thus, the combination of an increase in accessible antigen, normalization in TCR function, and better B-cell activation may help to explain the pathways to increased lupus autoantibodies under TNF blockade.


Localization (normalization) of TCR in B-cell associated with systemic lupus erythematosus
2) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374473 Disease Relevance 1.02 Pain Relevance 0.17
Ethics precluded further investigation in patients, and so we opted to study transendothelial migration of TCR?
Localization (migration) of TCR
3) Confidence 0.20 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.24 Pain Relevance 0.08
for 48 hours was performed essentially as described.19 Numbers of migrating TCR?
Localization (migrating) of TCR
4) Confidence 0.20 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0.28 Pain Relevance 0.11
-FITC (clone 6B10.2, which recognizes a transmembrane epitope of TCR?)
Localization (epitope) of TCR
5) Confidence 0.17 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0 Pain Relevance 0.07
Anti-mouse CD3e-PerCP (145-2C11; BioLegend, San Diego, CA), anti-mouse CD4-FITC (RM4-5; BD Pharmingen), anti-mouse DO-11.10 Clonotypic TCR (KJ1-26; BD Pharmingen), anti-mouse TCR V?
Localization (11.10) of TCR in 145-2C11
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.08 Pain Relevance 0

General Comments

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