INT21131

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.93
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ABAT)
Anatomy Link Frequency
brain 4
anterior 2
cortex 2
ABAT (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 85 100.00 Very High Very High Very High
Nicotine 12 99.98 Very High Very High Very High
Anterior cingulate 6 99.68 Very High Very High Very High
Anterior cingulate cortex 22 98.88 Very High Very High Very High
agonist 4 97.16 Very High Very High Very High
Neurotransmitter 9 97.02 Very High Very High Very High
GABAergic 68 96.12 Very High Very High Very High
Serotonin 7 88.96 High High
GABA receptor 4 87.36 High High
anticonvulsant 5 83.44 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 14 100.00 Very High Very High Very High
Myoclonus 17 99.92 Very High Very High Very High
Schizophrenia 122 99.28 Very High Very High Very High
Convulsion 13 99.28 Very High Very High Very High
Adenocarcinoma 3 99.12 Very High Very High Very High
Stress 6 90.64 High High
Panic Disorder 36 86.36 High High
Nicotine Addiction 68 85.48 High High
Affective Disorder 6 77.44 Quite High
Epilepsy 20 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Blockade of GABAA receptors or GABA synthesis regularly evokes convulsive seizures, but administration of many GABA agonists and some GABA uptake blockers paradoxically may evoke myoclonus.
Negative_regulation (Blockade) of Gene_expression (synthesis) of GABA associated with myoclonus, gaba, convulsion and agonist
1) Confidence 0.42 Published 1990 Journal FASEB J. Section Abstract Doc Link 2165012 Disease Relevance 1.40 Pain Relevance 0.56
In contrast to this observation, nicotine suppresses protein levels of GAD isozymes (mainly GAD65) and GABA in pancreatic ductal adenocarcinoma tissue [35].
Negative_regulation (suppresses) of Gene_expression (levels) of GABA associated with adenocarcinoma, gaba, generalized anxiety disorder and nicotine
2) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.89 Pain Relevance 0.31
Furthermore, expression levels of seven GABA-related transcripts have been found to be reduced in subjects with schizophrenia in four cortical regions (including the motor cortex); these changes may cause cortical dysfunction in schizophrenia patients (Hashimoto et al. 2008).
Negative_regulation (reduced) of Gene_expression (expression) of GABA in cortex associated with gaba and schizophrenia
3) Confidence 0.09 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.89 Pain Relevance 0.41
Another study revealed significantly decreased GABA concentration in the anterior cingulate (ACC) and in the basal ganglia in panic patients compared to controls (Ham et al. 2007).
Negative_regulation (decreased) of Gene_expression (concentration) of GABA in anterior associated with gaba, anterior cingulate cortex and anterior cingulate
4) Confidence 0.03 Published 2008 Journal J Neural Transm Section Body Doc Link PMC2694920 Disease Relevance 0.43 Pain Relevance 0.59
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Negative_regulation (inhibition) of Gene_expression (synthesis) of GABA in brain associated with gaba and neurotransmitter
5) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.65 Pain Relevance 0.48
In the human brain, VPA alters the activity of the neurotransmitter Gamma Amino Butyrate (GABA) by potentialising the inhibitory activity of GABA through several mechanisms, including inhibition of GABA degradation, inhibition of GABA Transaminobutyratre (ABAT), increased GABA synthesis, and decreased turnover [5].
Negative_regulation (inhibition) of Gene_expression (synthesis) of GABA in brain associated with gaba and neurotransmitter
6) Confidence 0.02 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.65 Pain Relevance 0.48

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