INT211315

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.97
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FGFR3) cytoplasmic membrane-bounded vesicle (FGFR3) plasma membrane (FGFR3)
Anatomy Link Frequency
synaptic cleft 2
muscle 1
vagus nerve 1
M-1 1
neuromuscular junction 1
FGFR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
vagus nerve 1 99.50 Very High Very High Very High
Inflammation 26 96.28 Very High Very High Very High
gABA 2 96.26 Very High Very High Very High
projection neuron 10 95.34 Very High Very High Very High
cytokine 4 89.04 High High
interneuron 4 86.40 High High
Catecholamine 5 84.00 Quite High
GABAergic 4 79.24 Quite High
depression 47 72.04 Quite High
chemokine 1 34.16 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 53 96.28 Very High Very High Very High
Pathologic Processes 1 94.40 High High
Disease 5 88.48 High High
Schizophrenia 1 86.00 High High
Supranuclear Palsy 1 84.64 Quite High
Depression 47 72.04 Quite High
Stress 21 70.28 Quite High
Critical Illness 2 47.68 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 43.92 Quite Low
Adhesions 3 35.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of ACh to two sites at a postsynaptic receptor was defined by the association rate constant kassociation identical for both sites, kassociation = 1.35 × 108 M-1· s-1.
ACh Binding (Binding) of in M-1
1) Confidence 0.35 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0
The model considers the stimulus-induced release of ACh into a synaptic cleft, ACh binding to two sites at a single postsynaptic receptor, and ACh hydrolysis.
ACh Binding (binding) of in synaptic cleft
2) Confidence 0.31 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.07 Pain Relevance 0.04
The hypothetical muscle relaxant D competes with ACh for binding to the same two sites at a postsynaptic receptor.
ACh Binding (binding) of in muscle
3) Confidence 0.23 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0
The model considers the stimulus-induced release of ACh into a synaptic cleft, ACh binding to two sites at a single postsynaptic receptor, and ACh hydrolysis.
ACh Binding (binding) of in synaptic cleft
4) Confidence 0.23 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0.07 Pain Relevance 0.04
Signal transmission across the neuromuscular junction results from a bimolecular reaction, i.e. from ACh binding to the postsynaptic receptors.
ACh Binding (binding) of in neuromuscular junction
5) Confidence 0.23 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC1939837 Disease Relevance 0 Pain Relevance 0
As a result, the striatal projection neurons would be more strongly suppressed by the GABA interneurons in the striosomes than in the matrix and, therefore, the influence on the output structures would vary considerably between the two compartments depending on their relative amount of ACh (Fig. 6B).
ACh Binding (amount) of in interneurons associated with gaba and projection neuron
6) Confidence 0.08 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2137841 Disease Relevance 0.50 Pain Relevance 0.37
In this pathway, the efferent activity in the vagus nerve releases acetylcholine (ACh), which interacts specifically with macrophage ?
ACh Binding (interacts) of in vagus nerve associated with vagus nerve
7) Confidence 0.03 Published 2010 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2883961 Disease Relevance 0.33 Pain Relevance 0.31

General Comments

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