INT21132

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Context Info
Confidence 0.33
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 36
Total Number 40
Disease Relevance 11.32
Pain Relevance 17.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GABRB3) transport (GABRB3) plasma membrane (GABRB3)
transmembrane transport (GABRB3)
Anatomy Link Frequency
epithelium 4
fascicles 2
spinal 1
dorsal root ganglion 1
cortex 1
GABRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 1829 100.00 Very High Very High Very High
GABAergic 1565 99.88 Very High Very High Very High
unmyelinated 494 99.86 Very High Very High Very High
spinal dorsal horn 26 99.68 Very High Very High Very High
Neuropathic pain 39 99.56 Very High Very High Very High
c fibre 546 99.50 Very High Very High Very High
Cannabinoid receptor 266 99.14 Very High Very High Very High
dorsal root ganglion 169 99.00 Very High Very High Very High
cannabis 52 99.00 Very High Very High Very High
Central nervous system 53 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 272 100.00 Very High Very High Very High
Neuropathic Pain 52 99.56 Very High Very High Very High
Myoclonus 17 99.44 Very High Very High Very High
Lifespan 513 99.28 Very High Very High Very High
Convulsion 1 99.28 Very High Very High Very High
Ganglion Cysts 169 99.00 Very High Very High Very High
Anxiety Disorder 158 98.92 Very High Very High Very High
Aging 323 98.64 Very High Very High Very High
Cannabis Dependence 24 94.96 High High
Schizophrenia 106 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 13 GABAergic genes expressed in the small airway epithelium of nonsmokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRG1, GABRG3, GABRE, GABRP, GABRR2, GABBR1; transport-related genes GAT-1,GAT-2 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of GABRB3 in epithelium associated with gaba and gabaergic
1) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.41 Pain Relevance 0.61
The 13 GABAergic genes expressed in the large airway epithelium of nonsmokers included synthesis-related genes GAD67; receptors GABRB2, GABRB3, GABRE, GABRP, GABRR2, GABBR1, GABBR2; transport-related genes GAT-1,GAT-2, BGT-1 and metabolism-related genes GABA-T, ALDH5A1.
Gene_expression (expressed) of GABRB3 in epithelium associated with gaba and gabaergic
2) Confidence 0.33 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.24 Pain Relevance 0.72
The data establishes the functional expression of GABAA receptors in the axonal membrane of a sub-population of unmyelinated afferent human nerve fibres that most probably comprises nociceptors.
Gene_expression (expression) of GABAA in nociceptors associated with nociceptor and unmyelinated
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.33 Pain Relevance 1.01
If the functional GABAA receptor expression in peripheral human unmyelinated axons extends further to the centrally projecting axons of sensory neurones, this observation provides considerable impetus for the translation of GABAA receptor targeted strategies to humans.


Gene_expression (expression) of GABAA receptor associated with unmyelinated
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.27 Pain Relevance 0.78
This restriction of GABA sensitivity to a subset of fascicles may reflect a selective expression of GABAA receptors in a sub-population of human unmyelinated axons.
Gene_expression (expression) of GABAA in fascicles associated with gaba and unmyelinated
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.58
C-fibre responses to GABA were restricted to a subset of human nerve fascicles which is consistent with the notion that only a subpopulation of human unmyelinated axons expresses functional GABAA receptors.
Gene_expression (expresses) of GABAA in fascicles associated with c fibre, gaba and unmyelinated
6) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.06 Pain Relevance 0.86
The demonstration of functional GABAA responses in human unmyelinated axons supplements the body of work showing that GABAA receptors are functionally expressed in axons in the mammalian peripheral and central nervous system [1], [13], [28] and may have implications for the pathogenesis of some forms of neuropathy.
Gene_expression (expressed) of GABAA in central nervous system associated with neuropathic pain, central nervous system and unmyelinated
7) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.29 Pain Relevance 0.76
Blockade of GABAA receptors or GABA synthesis regularly evokes convulsive seizures, but administration of many GABA agonists and some GABA uptake blockers paradoxically may evoke myoclonus.
Gene_expression (synthesis) of GABAA associated with myoclonus, gaba, convulsion and agonist
8) Confidence 0.23 Published 1990 Journal FASEB J. Section Abstract Doc Link 2165012 Disease Relevance 1.40 Pain Relevance 0.56
2-subunit of the GABAA receptor, which is thought to be responsible for the anxiolytic effects of benzodiazepines (Low et al. 2000), without having affinity for the ?
Gene_expression (thought) of GABAA receptor associated with anxiety disorder
9) Confidence 0.23 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695548 Disease Relevance 0.62 Pain Relevance 0.17
The increase in human C-fibre electrical excitability seen in response to GABA was mediated by GABAA receptors.
Gene_expression (receptors) of GABAA associated with c fibre and gaba
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.38 Pain Relevance 0.82
C-fibre responses to bath applied GABA (10 µM) were mediated by GABAA receptors, being mimicked by muscimol (10 µM, n?
Gene_expression (receptors) of GABAA associated with c fibre and gaba
11) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0 Pain Relevance 0.81
METHODS: Heteromeric human neuronal nicotinic acetylcholine receptors (hnAChR channels alpha2beta2, alpha2beta4, alpha3beta2, alpha3beta4, alpha4beta2 and alpha4beta4), 5-hydroxytryptamine3 (5-HT3), alpha1beta2gamma2S gamma-aminobutyric acid type A (GABAA) and alpha1 glycine receptors were expressed in Xenopus oocytes, and effects of ketamine and dizocilpine were studied using the two-electrode voltage-clamp technique.
Gene_expression (expressed) of GABAA in oocytes
12) Confidence 0.22 Published 2000 Journal Anesthesiology Section Body Doc Link 10754635 Disease Relevance 0 Pain Relevance 0
Indeed current therapeutic strategies currently being developed in mice are aimed at reversing this GABAergic disinhibition through sub-type selective activation of GABAA receptors expressed in the spinal dorsal horn [50].
Gene_expression (expressed) of GABAA in spinal associated with spinal dorsal horn and gabaergic
13) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.29 Pain Relevance 0.86
However it has not been established whether the axons of human primary sensory neurones express functional GABAA receptors.
Spec (whether) Gene_expression (express) of GABAA
14) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.25 Pain Relevance 0.94
The presence of GABAA receptors on the unmyelinated axons of primary sensory neurones is central to this concept.
Gene_expression (presence) of GABAA associated with unmyelinated
15) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.33 Pain Relevance 0.85
The cell bodies of dorsal root ganglion (DRG) neurones, which are devoid of synaptic contact, express functional GABAA receptors (human: [4], [5], rat: [6], [7], cat: [8], rabbit: [9], chick: [10]).
Gene_expression (express) of GABAA in dorsal root ganglion associated with ganglion cysts and dorsal root ganglion
16) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.44 Pain Relevance 0.46
In adult visual cortex, activity regulates GABAA receptor expression (Hendry et al., 1994) and during aging the loss of orientation tuning in visual cortical receptive fields (Leventhal et al., 2003) and changes in visual perception (Betts et al., 2005) have been linked with an overall loss of GABA.
Gene_expression (expression) of GABAA receptor in cortex associated with gaba and aging
17) Confidence 0.20 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.17 Pain Relevance 0.24
GABA increases C-fibre axonal excitability via GABAA receptors
Gene_expression (receptors) of GABAA associated with c fibre and gaba
18) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808338 Disease Relevance 0.19 Pain Relevance 1.04
Functional GABAA receptors are present on a subset of unmyelinated primary afferents in humans and their activation depolarizes these axons, an effect likely due to an elevated intra-axonal chloride concentration.
Gene_expression (present) of GABAA associated with unmyelinated
19) Confidence 0.18 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2808338 Disease Relevance 0.18 Pain Relevance 0.89
Previous studies have shown that a specific excitatory-inhibitory balance and expression of the GABAA?
Gene_expression (expression) of GABAA
20) Confidence 0.18 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.49 Pain Relevance 0.23

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