INT211363

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Context Info
Confidence 0.22
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 13.26
Pain Relevance 6.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (RENBP)
Anatomy Link Frequency
chondrocytes 1
joint 1
RENBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 408 99.98 Very High Very High Very High
Kinase C 20 99.98 Very High Very High Very High
Fibrositis 28 99.62 Very High Very High Very High
Pain 261 98.78 Very High Very High Very High
depression 44 97.92 Very High Very High Very High
backache 24 89.04 High High
Arthritis 22 87.48 High High
Rheumatism 12 79.12 Quite High
headache 12 78.20 Quite High
Migraine 14 77.92 Quite High
Disease Link Frequency Relevance Heat
Pain 659 99.98 Very High Very High Very High
Diabetes Mellitus 290 99.66 Very High Very High Very High
Fibromyalgia 28 99.62 Very High Very High Very High
Aging 46 99.16 Very High Very High Very High
Arthralgia 6 98.78 Very High Very High Very High
Syndrome 17 98.38 Very High Very High Very High
Hyperglycemia 128 98.08 Very High Very High Very High
Genetic Predisposition To Disease 2 98.04 Very High Very High Very High
Depression 44 97.92 Very High Very High Very High
Stress 89 96.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prevalence of depression was twice the rate among those who reported chronic pain as among those who did not and appeared to be related to age for both males and females (Figure 9).
Positive_regulation (related) of age associated with depression and lasting pain
1) Confidence 0.22 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096686 Disease Relevance 2.25 Pain Relevance 1.41
Across age and sex, the majority of those with chronic pain had three or more chronic conditions, whose prevalence increased with age for both sexes (Figure 6).
Positive_regulation (increased) of age associated with lasting pain
2) Confidence 0.22 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096686 Disease Relevance 2.11 Pain Relevance 1.73
The prevalence of chronic pain increased with age in both sexes (Figure 3).
Positive_regulation (increased) of age associated with lasting pain
3) Confidence 0.22 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096686 Disease Relevance 1.88 Pain Relevance 1.71
For certain pain syndromes, such as joint pain, chronic widespread pain and fibromyalgia, prevalence rates increase with age.[15] Not surprisingly, therefore, chronic pain is also associated with multiple comorbid conditions.[9] As well, some studies have consistently found an association between chronic pain and lower educational levels and socio-economic status.[12,13,16] Psychological distress is common in both men and women who experience chronic pain, depression being a common, strong correlate.[7,17] Estimates of depression prevalence among patients with chronic pain range from 31% to 100%,[18] and pain complaints in depressed individuals range from 34% to 66%.[19] This is particularly a concern for women, as they suffer from clinical depression at twice the rate of men.
Neg (Not) Positive_regulation (increase) of age in joint associated with pain, arthralgia, depression, syndrome, lasting pain and fibrositis
4) Confidence 0.22 Published 2004 Journal BMC Womens Health Section Body Doc Link PMC2096686 Disease Relevance 1.89 Pain Relevance 1.51
Nerlich et al 27 found that collagen type X was expressed by nuclear chondrocytes at a higher age and was associated with advanced degenerative disc alterations.
Positive_regulation (higher) of age in chondrocytes
5) Confidence 0.06 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.41 Pain Relevance 0
The risk of T2D also rises with increasing age [5].
Positive_regulation (increasing) of age associated with diabetes mellitus
6) Confidence 0.06 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 1.16 Pain Relevance 0
Analysis of rs1111875 with fasting glucose under a co-dominant model showed a significant association of the age × rs1111875 (heterozygote vs major homozygote) interaction term with fasting glucose level (Table 4; p = 0.03), suggesting that one copy of the A non-risk allele at rs1111875 increases fasting glucose level with increasing age.
Positive_regulation (increasing) of age
7) Confidence 0.06 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2958899 Disease Relevance 0.29 Pain Relevance 0
Thus, at least for most of the RBCs, age was not a significant determinant of the observed differences in hydration rate and hence of Pcat activation.
Neg (not) Positive_regulation (activation) of age
8) Confidence 0.05 Published 2007 Journal Blood Section Body Doc Link PMC1939906 Disease Relevance 0.28 Pain Relevance 0
Earlier research in both diabetic animals and humans revealed an association between the accumulation of AGE-modified proteins and the severity of microvascular complications.
Positive_regulation (accumulation) of AGE associated with diabetes mellitus
9) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.01 Pain Relevance 0.07
Oxidative stress is probably a key event in endothelial dysfunction since inhibition of hyperglycemia, induced, ROS production prevents activation of the aldose reductase, hexosamine pathways, PKC activation, and AGE formation [77, 89].
Positive_regulation (activation) of AGE associated with hyperglycemia, stress and kinase c
10) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.79 Pain Relevance 0.05
While AGE accumulation is a normal part of aging, it occurs at an accelerated rate in diabetes where progressive modifications can lead to irreversible cross-linking, impairing the actions of other molecules [64, 65].
Positive_regulation (accumulation) of AGE associated with aging and diabetes mellitus
11) Confidence 0.02 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2825545 Disease Relevance 1.19 Pain Relevance 0
Demographic variables presented by age group (Table 3b) show that the proportion of males increased with age (21.2% in 50–59 age group vs. 30% in the 80+ age group; p=0.001); the younger age group was better educated (24.4% in the 50–59 age group vs. 4.9% in 80+ have 6 years or more of formal education; p<0.001); the two younger age groups have higher socio-economic status (26.0 and 26.7% in the younger groups vs. 20.2 and 20.0% in the older age groups; p<0.001).
Positive_regulation (increased) of age
12) Confidence 0.02 Published 2010 Journal Global Health Action Section Body Doc Link PMC2957314 Disease Relevance 0 Pain Relevance 0
Seven out of eight sera with IgG reactivity against modified food antigens showed significant elevation against AGE-HSA, AGE-Hb, ox-LDL and MBP (Table 2).
Positive_regulation (elevation) of AGE-Hb
13) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0 Pain Relevance 0
For example, Sample #4 with IgG immune reaction against 16 out of 45 modified food antigens showed simultaneous elevation in antibodies against AGE-HSA (120 EU), AGE-Hb (111 EU), ox-LDL (2,431 mU) and MBP (129 EU).
Positive_regulation (elevation) of AGE-Hb
14) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2685801 Disease Relevance 0 Pain Relevance 0

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