INT211375

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.44
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TYMP) cytosol (TYMP) small molecule metabolic process (TYMP)
Anatomy Link Frequency
white blood cells 4
TYMP (Homo sapiens)
Pain Link Frequency Relevance Heat
Hypoesthesia 2 94.20 High High
abdominal pain 1 88.40 High High
fibrosis 1 78.36 Quite High
Pain 2 44.64 Quite Low
imagery 4 23.92 Low Low
palliative 6 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 6 95.44 Very High Very High Very High
Hypesthesia 2 94.20 High High
Ocular Toxicity (including Many Sub-types) 5 92.12 High High
Ophthalmoplegia 4 91.80 High High
Cancer 54 91.36 High High
Abdominal Pain 1 88.40 High High
Diverticulum 4 87.52 High High
Advanced Or Metastatic Breast Cancer 27 87.44 High High
Dysphagia 2 87.40 High High
Vomiting 2 86.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have no knowledge concerning kinetics of a possible TP induction in human white blood cells (e.g. start of thymidine phosphorylase up-regulation, maximum expression level after single dose, decline of thymidine phosphorylase expression after a single dose of the modulating drug, maximum expression level reached under repeated administration).
Spec (possible) Regulation (regulation) of Gene_expression (expression) of thymidine phosphorylase in white blood cells
1) Confidence 0.43 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.43 Pain Relevance 0
We have no knowledge concerning kinetics of a possible TP induction in human white blood cells (e.g. start of thymidine phosphorylase up-regulation, maximum expression level after single dose, decline of thymidine phosphorylase expression after a single dose of the modulating drug, maximum expression level reached under repeated administration).
Spec (possible) Regulation (regulation) of Gene_expression (expression) of thymidine phosphorylase in white blood cells
2) Confidence 0.43 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.42 Pain Relevance 0
As consequence, the putative up-regulation of thymidine phosphorylase expression by paclitaxel would translate into modulatory benefit with negligible time delay in humans.
Regulation (regulation) of Gene_expression (expression) of thymidine phosphorylase
3) Confidence 0.26 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.22 Pain Relevance 0
Diagnostic studies including a colonoscopy ruled out mechanical causes of obstruction and a diagnosis of MNGIE had been made on the basis of an increased levels of dThd (9.3 ?
Regulation (ruled) of Gene_expression (diagnosis) of MNGIE
4) Confidence 0.16 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3018369 Disease Relevance 1.36 Pain Relevance 0.22

General Comments

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