INT211377

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TYMP) cytosol (TYMP) small molecule metabolic process (TYMP)
Anatomy Link Frequency
blood cells 4
white blood cells 2
TYMP (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 46.28 Quite Low
Serotonin 4 45.44 Quite Low
dexamethasone 4 40.76 Quite Low
Taxol 4 34.96 Quite Low
Inflammation 4 26.28 Quite Low
palliative 8 16.48 Low Low
Disease Link Frequency Relevance Heat
Cancer 72 88.04 High High
Advanced Or Metastatic Breast Cancer 36 82.40 Quite High
Breast Cancer 8 75.00 Quite High
Malignant Neoplastic Disease 8 40.80 Quite Low
Death 4 33.16 Quite Low
Convulsion 4 28.80 Quite Low
Diabetes Mellitus 4 27.24 Quite Low
Inflammatory Bowel Disease 4 26.84 Quite Low
Cervical Cancer 4 19.96 Low Low
Toxicity 36 16.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have no knowledge concerning kinetics of a possible TP induction in human white blood cells (e.g. start of thymidine phosphorylase up-regulation, maximum expression level after single dose, decline of thymidine phosphorylase expression after a single dose of the modulating drug, maximum expression level reached under repeated administration).
Negative_regulation (decline) of Gene_expression (expression) of thymidine phosphorylase in white blood cells
1) Confidence 0.56 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.36 Pain Relevance 0
In eight paclitaxel naive patients, the expression of thymidine phosphorylase in peripheral mononuclear blood cells temporarily decreased under infusion with paclitaxel equilibrating within 24 h to enzyme levels observed prior to therapy (Figure 1).
Negative_regulation (decreased) of Gene_expression (expression) of thymidine phosphorylase in blood cells
2) Confidence 0.41 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.07 Pain Relevance 0
The expression of thymidine phosphorylase was assessed in duplicates using an ELISA according to the manufacturer's instructions (Thymidine Phosphorylase ELISA; Roche, Mannheim, Germany).
Negative_regulation (assessed) of Gene_expression (expression) of thymidine phosphorylase
3) Confidence 0.41 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.05 Pain Relevance 0
The expression of TP in peripheral mononuclear blood cells decreased significantly after infusion below pretherapeutic values (p = 0.023; n = 8).
Negative_regulation (decreased) of Gene_expression (expression) of TP in blood cells
4) Confidence 0.36 Published 2007 Journal BMC Clin Pharmacol Section Abstract Doc Link PMC1939983 Disease Relevance 0.21 Pain Relevance 0

General Comments

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