INT211378

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TYMP) cytosol (TYMP) small molecule metabolic process (TYMP)
Anatomy Link Frequency
blood cells 1
TYMP (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 1 76.72 Quite High
peripheral neuropathy 8 70.80 Quite High
Multiple sclerosis 10 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 18 91.92 High High
Neutropenia 7 87.56 High High
Toxicity 9 85.88 High High
Disease 20 83.76 Quite High
Syndrome 6 79.68 Quite High
Liver Failure 1 74.96 Quite High
Epilepsy 1 73.36 Quite High
Ataxia 11 71.44 Quite High
Peripheral Neuropathy 8 70.80 Quite High
Muscle Disease 9 68.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Especially the temporary decrease of TP levels in blood cells clearly points at a favourable time profile for the combination of both compounds.
Negative_regulation (decrease) of TP in blood cells
1) Confidence 0.56 Published 2007 Journal BMC Clin Pharmacol Section Body Doc Link PMC1939983 Disease Relevance 0.81 Pain Relevance 0
Over the past decade, a growing number of nuclear genetic defects have been identified that disrupt mitochondrial function either by a reduction in mtDNA copy number, and/or the accumulation of secondary mtDNA deletions: POLG1, POLG2, PEO1, SLC25A4, TYMP, DGUOK, TK2, SUCLA2, SUCLG1, MPV17 and RRM2B (Hudson and Chinnery, 2006; Chinnery and Zeviani, 2008; Copeland, 2008).
Negative_regulation (reduction) of TYMP
2) Confidence 0.36 Published 2010 Journal Brain Section Body Doc Link PMC2842512 Disease Relevance 0.64 Pain Relevance 0.07

General Comments

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