INT21138

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Context Info
Confidence 0.48
First Reported 1984
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 5.57
Pain Relevance 6.80

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signal transduction (ADRA2A) small molecule metabolic process (ADRA2A) plasma membrane (ADRA2A)
cytoplasm (ADRA2A) signal transducer activity (ADRA2A)
Anatomy Link Frequency
platelet 8
adipocyte 1
ADRA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 37 100.00 Very High Very High Very High
Clonidine 31 100.00 Very High Very High Very High
antidepressant 9 100.00 Very High Very High Very High
Dopamine 8 100.00 Very High Very High Very High
antagonist 16 99.60 Very High Very High Very High
Catecholamine 13 99.52 Very High Very High Very High
Serotonin 2 99.52 Very High Very High Very High
Angina 3 99.36 Very High Very High Very High
monoamine 1 98.04 Very High Very High Very High
depression 4 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Anxiety Disorder 7 99.96 Very High Very High Very High
Cv General 3 Under Development 3 99.36 Very High Very High Very High
Pressure Volume 2 Under Development 8 97.96 Very High Very High Very High
Disease 1 97.12 Very High Very High Very High
Panic Disorder 23 97.08 Very High Very High Very High
Schizophrenia 6 97.04 Very High Very High Very High
Depression 7 96.16 Very High Very High Very High
Coronary Artery Disease 5 93.48 High High
Obesity 10 91.84 High High
Hypersensitivity 4 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding approaches performed with [3H]UK and [3H]CLO; two imidazoline derivatives exhibiting full and partial agonist properties, respectively, in biological assays clearly indicate that: 1) partial and full agonists label an equivalent number of binding sites corresponding to the high affinity form of the alpha-2 receptor; 2) there is some correlation between the KiH/KiL ratio defined in competition of [3H]yohimbine binding and the intrinsic activity defined in biological assays; 3) differences exist between the dissociation of the full-agonist ([3H]UK) and the partial-agonist ([3H]CLO); 4) the interaction of the full agonist with the alpha-2 receptor promotes the formation of an agonist-alpha-2 receptor-Gi protein complex (HRGi) complex which is more stable than that obtained with the partial agonist as objectivated by the sensitivity to the effects of guanosine 5'-(imido)triphosphate and N-ethylmaleimide; 5) the full-agonist is characterized by a "tight agonist binding" which is not observed with the partial agonist.
alpha-2 receptor Binding (interaction) of associated with agonist
1) Confidence 0.48 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2566682 Disease Relevance 0.14 Pain Relevance 0.82
Kd did not correlate with any of these variables not with the Bmax of platelet alpha 2-adrenergic binding.
platelet alpha 2-adrenergic Binding (binding) of in platelet
2) Confidence 0.46 Published 1985 Journal J Psychiatr Res Section Abstract Doc Link 3001300 Disease Relevance 0.26 Pain Relevance 0.13
Specific binding of tritiated clonidine, an alpha 2-adrenergic receptor agonist, and tritiated yohimbine, an alpha 2-adrenergic receptor antagonist, to platelet membranes was measured in persons with panic attacks or major depression and in normal subjects.
alpha 2-adrenergic Binding (binding) of in platelet associated with panic disorder, depression, antagonist, agonist and clonidine
3) Confidence 0.46 Published 1984 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 6095785 Disease Relevance 0.48 Pain Relevance 0.42
Specific binding of tritiated clonidine, an alpha 2-adrenergic receptor agonist, and tritiated yohimbine, an alpha 2-adrenergic receptor antagonist, to platelet membranes was measured in persons with panic attacks or major depression and in normal subjects.
alpha 2-adrenergic Binding (binding) of in platelet associated with panic disorder, depression, antagonist, agonist and clonidine
4) Confidence 0.46 Published 1984 Journal Arch. Gen. Psychiatry Section Abstract Doc Link 6095785 Disease Relevance 0.55 Pain Relevance 0.43
Platelet alpha 2-adrenergic receptor binding and plasma catecholamines.
alpha 2-adrenergic Binding (binding) of in Platelet associated with catecholamine
5) Confidence 0.40 Published 1984 Journal Arch. Gen. Psychiatry Section Title Doc Link 6095785 Disease Relevance 0.58 Pain Relevance 0.47
Alpha 2-adrenergic receptor changes during antidepressant treatment were studied using 3H-yohimbine binding to human platelet membranes and clonidine-induced hypotension.
Alpha 2-adrenergic Binding (binding) of in platelet associated with antidepressant, pressure volume 2 under development and clonidine
6) Confidence 0.37 Published 1989 Journal Biol. Psychiatry Section Abstract Doc Link 2539204 Disease Relevance 0.33 Pain Relevance 0.38
Alpha 2-adrenergic receptors measured by 3H-yohimbine binding were not significantly changed following antidepressant treatment.
Alpha 2-adrenergic Binding (binding) of associated with antidepressant
7) Confidence 0.37 Published 1989 Journal Biol. Psychiatry Section Abstract Doc Link 2539204 Disease Relevance 0.36 Pain Relevance 0.43
No significant association between the ADRA2A C-1291G polymorphism and polydipsia was found.
ADRA2A Neg (No) Binding (association) of
8) Confidence 0.33 Published 2009 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 19439247 Disease Relevance 0.43 Pain Relevance 0.16
The experiments on dissociation kinetics, however, suggest that the observed deviation of [3H]yohimbine binding from the simple mass action kinetics is most likely due to negative cooperative interactions among alpha2-adrenoceptor sites.
alpha2-adrenoceptor Neg (negative) Binding (interactions) of
9) Confidence 0.29 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2865159 Disease Relevance 0 Pain Relevance 0.22
Both drugs behaved as potent antagonists of epinephrine-induced platelet aggregation. [3H]Yohimbine binding studies revealed that the drugs bind to the alpha 2 adrenergic receptor of human platelets.
alpha 2 adrenergic receptor Binding (bind) of in platelets associated with antagonist
10) Confidence 0.26 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 2871841 Disease Relevance 0.07 Pain Relevance 0.28
Increase in human platelet alpha 2-adrenergic receptor affinity for agonist in unstable angina.
platelet alpha 2-adrenergic Binding (affinity) of in platelet associated with angina and agonist
11) Confidence 0.25 Published 1985 Journal J. Lab. Clin. Med. Section Title Doc Link 2866219 Disease Relevance 0.59 Pain Relevance 0.53
On the other hand, the adrenergic binding to adipocyte membranes from hypothyroid subjects was reduced, and the beta-receptor binding was reduced even much more (50%) than the alpha 2-receptor binding (20%, P less than .01).
alpha 2-receptor Binding (binding) of in adipocyte
12) Confidence 0.21 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 2823049 Disease Relevance 0.83 Pain Relevance 0.36
Adrenergic status in anxiety disorders: platelet alpha 2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorder patients and in normal subjects.
platelet alpha 2-adrenergic Binding (binding) of in platelet associated with catecholamine and anxiety disorder
13) Confidence 0.18 Published 1990 Journal Biol. Psychiatry Section Title Doc Link 2165422 Disease Relevance 0.46 Pain Relevance 0.34
CONCLUSIONS: The effects of DEX are not limited to its interactions with alpha2-adrenergic receptors.
alpha2-adrenergic Binding (interactions) of
14) Confidence 0.13 Published 2009 Journal Br J Anaesth Section Body Doc Link 19542547 Disease Relevance 0 Pain Relevance 0
SNL did not alter total alpha2-adrenergic receptor number or affinity to [3H]-rauwolscine binding, and displacement studies with the alpha2A-adrenergic antagonist BRL44408 revealed that most of the binding was associated with the alpha2A-adrenergic subtype.
alpha2A-adrenergic Binding (associated) of associated with antagonist and spinal nerve ligature
15) Confidence 0.02 Published 2005 Journal Brain Res. Section Abstract Doc Link 15748875 Disease Relevance 0.12 Pain Relevance 1.08
Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity.
alpha2A-adrenergic Binding (Interaction) of associated with antidepressant, dopamine and monoamine
16) Confidence 0.01 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9223549 Disease Relevance 0.37 Pain Relevance 0.76

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