INT211384

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (FASN) small molecule metabolic process (FASN) lyase activity (FASN)
Golgi apparatus (FASN) cytoplasm (FASN) cytosol (FASN)
FASN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 37 96.88 Very High Very High Very High
Endocannabinoid 1 96.08 Very High Very High Very High
monoamine 1 93.88 High High
tolerance 3 49.04 Quite Low
Bioavailability 9 14.96 Low Low
ischemia 1 6.16 Low Low
Inflammation 11 5.00 Very Low Very Low Very Low
local anesthetic 11 5.00 Very Low Very Low Very Low
agonist 9 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 11 98.84 Very High Very High Very High
Fungal Infection 7 98.10 Very High Very High Very High
Overweight 2 85.60 High High
Sprains And Strains 5 82.80 Quite High
Cancer 131 80.24 Quite High
Glioma 1 70.24 Quite High
Endometriosis (extended) 7 62.20 Quite High
Carcinoma 2 55.64 Quite High
Diabetes Mellitus 7 52.64 Quite High
Impaired Glucose Tolerance 2 50.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Currently, transcriptional profiles of T. rubrum response to three antifungal agents are integrated into TrED, including ketoconazole, amphotericin B and a novel synthetic fatty acid synthase inhibitor PHS11A [8,9].
Negative_regulation (inhibitor) of fatty acid synthase associated with fungal infection
1) Confidence 0.41 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1940010 Disease Relevance 0.18 Pain Relevance 0
Orlistat is a potent inhibitor of Fatty acid synthase (FAS) activity, a key metabolic enzyme responsible for the terminal catalytic step in novo fatty acid biosynthesis [283].
Negative_regulation (inhibitor) of Fatty acid synthase
2) Confidence 0.38 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 1.01 Pain Relevance 0.14

General Comments

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