INT211489

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.88
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARHGAP4) signal transduction (ARHGAP4) nucleolus (ARHGAP4)
nucleus (ARHGAP4) intracellular (ARHGAP4) cytoskeleton organization (ARHGAP4)
Anatomy Link Frequency
PGE2 1
ARHGAP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 10 95.40 Very High Very High Very High
Serotonin 33 91.04 High High
Glutamate 77 89.92 High High
COX-2 inhibitor 17 88.24 High High
antagonist 6 65.92 Quite High
imagery 6 58.56 Quite High
nMDA receptor 7 16.16 Low Low
ischemia 9 14.72 Low Low
excitatory amino acid 9 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 64 100.00 Very High Very High Very High
Optic Nerve Injuries 35 93.92 High High
Injury 39 91.44 High High
Glaucoma 33 90.96 High High
Nervous System Injury 1 89.16 High High
Apoptosis 67 82.72 Quite High
Optic Disorders 8 80.00 Quite High
Ganglion Cysts 30 79.52 Quite High
Handedness 12 74.28 Quite High
Retinal Detachment 5 69.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
which leads to extensive RGC death, the GLT1 protein levels were
Gene_expression (death) of RGC associated with death
1) Confidence 0.65 Published 2007 Journal Experimental Diabetes Research Section Body Doc Link PMC1940058 Disease Relevance 1.18 Pain Relevance 0.29
Naïve and injured RGCs expressed TRADD and c-fos as seen by colocalization of the fluorogold tracer and red fluorescence immunoreactivity.
Gene_expression (expressed) of RGC
2) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2426719 Disease Relevance 0.86 Pain Relevance 0
Our studies showed that COX-2 positive pressurized RGCs synthesize PGE2.
Gene_expression (synthesize) of RGC in PGE2
3) Confidence 0.65 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688370 Disease Relevance 0.62 Pain Relevance 0.12
In addition, as indicated by many red labeled cells, not all Brn3a-positive RGCs expressed GFP.
Gene_expression (expressed) of RGC
4) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2793898 Disease Relevance 0.07 Pain Relevance 0
The ectopic expression of Zic2 in cRGCs leads to a lack-of-refinement phenotype of their axons, a defect that is partially reverted after application of fluoxetine indicating, at least in part, this phenotype is caused by induction of Sert.
Gene_expression (expression) of RGC associated with fluoxetine
5) Confidence 0.65 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.18
The merged panel (Figure 2F) shows Thy1.2-labeled RGCs that were negative for GFP.


Neg (negative) Gene_expression (negative) of RGC
6) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2793898 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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