INT211533

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Context Info
Confidence 0.62
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Kit) cell differentiation (Kit) extracellular space (Kit)
plasma membrane (Kit) nucleus (Kit) kinase activity (Kit)
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 3 39.76 Quite Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Injury 3 90.96 High High
Sprains And Strains 9 76.52 Quite High
Macrocytic Anemia 3 74.08 Quite High
Lipodystrophy 6 43.84 Quite Low
Targeted Disruption 3 25.92 Quite Low
Death 3 24.56 Low Low
Hematological Disease 18 18.28 Low Low
Anaemia 15 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 12 5.00 Very Low Very Low Very Low
Hyperlipidemia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the data support that the mutants described here represent a new allelic series at the Kit locus, with three missense mutations (Sco1, Sco5 and Whc1) and one probable mutation affecting the regulation of the Kit gene (Sow3).
Spec (probable) Regulation (affecting) of Spec (probable) Regulation (regulation) of Kit
1) Confidence 0.62 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.24 Pain Relevance 0
In this paper, we described three new point mutations inducing loss-of-function of the KIT protein (Sco1, Sco5 and Whc1) and one potential mutation affecting the regulation of the Kit gene (Sow3).
Regulation (affecting) of Regulation (regulation) of Kit
2) Confidence 0.27 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0
Most of them correspond to large chromosomal rearrangement whereas Sow3 is presumably a point mutation induced by ENU affecting a regulatory element controlling Kit during melanogenesis and gametogenesis.
Regulation (affecting) of Regulation (controlling) of Kit
3) Confidence 0.24 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0 Pain Relevance 0

General Comments

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