INT211538

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.28
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lpin1) endoplasmic reticulum (Lpin1) nucleus (Lpin1)
lipid metabolic process (Lpin1) cytoplasm (Lpin1)
Anatomy Link Frequency
liver 2
juvenile 1
Lpin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 6 70.24 Quite High
isoflurane 12 5.00 Very Low Very Low Very Low
imagery 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 99.92 Very High Very High Very High
Hyperlipidemia 18 93.16 High High
Anaemia 30 76.72 Quite High
Lipodystrophy 12 76.08 Quite High
Fatty Liver 6 73.92 Quite High
Hematological Disease 36 71.40 Quite High
Disorder Of Lipid Metabolism 24 45.12 Quite Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Cancer 12 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, downregulation of Lpin1 in Kit mutants will lead to a reduced oxidation of lipids and steatosis in a context of increased lipid delivery during suckling.
Negative_regulation (downregulation) of Lpin1
1) Confidence 0.57 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.29 Pain Relevance 0
In such a way, Kit loss-of-function mimicked the downregulation of Lpin1, Lpl and Vldlr leading to juvenile steatosis and growth retardation.
Negative_regulation (downregulation) of Lpin1 in juvenile
2) Confidence 0.57 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.37 Pain Relevance 0
Expression profiling for key genes participating to the metabolism, the transport, the modification, lipidogenesis and biliary acid synthesis in the liver revealed that only a few genes, namely Vldlr, Lpin1 and Lpl were downregulated in Kit mutants.
Negative_regulation (downregulated) of Lpin1 in liver
3) Confidence 0.57 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.09 Pain Relevance 0
The downregulation of Lpin1 started to be detected at 1.5 dpp and was significant at 2.5 dpp when homozygote Sco5 mutants suffer from the clearance of microvesicular accumulated lipids.
Negative_regulation (downregulation) of Lpin1
4) Confidence 0.57 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.07 Pain Relevance 0.04
In addition to the Lpin1 downregulation, repression of Lpl and Vldlr would also contribute to the hepatic Kit-induced phenotype.
Negative_regulation (downregulation) of Lpin1 associated with repression
5) Confidence 0.57 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.39 Pain Relevance 0
We found that, in addition to the classical phenotypes, mutations of Kit induced juvenile steatosis, associated with the downregulation of the three genes, VldlR, Lpin1 and Lpl, controlling lipid metabolism in the post-natal liver.
Negative_regulation (downregulation) of Lpin1 in liver
6) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Abstract Doc Link PMC1940254 Disease Relevance 0.07 Pain Relevance 0

General Comments

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