INT211546

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.71
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lpl) extracellular region (Lpl) plasma membrane (Lpl)
lipid metabolic process (Lpl)
Anatomy Link Frequency
gut 2
CII 1
Lpl (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 14 98.52 Very High Very High Very High
alcohol 11 80.24 Quite High
imagery 24 78.88 Quite High
agonist 30 37.04 Quite Low
tolerance 18 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Angina 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 58 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 297 99.80 Very High Very High Very High
Hyperlipidemia 5 96.78 Very High Very High Very High
Overweight 7 90.72 High High
Fatty Liver 1 62.72 Quite High
Lipodystrophy 2 58.56 Quite High
Toxicity 2 57.20 Quite High
Liver Cancer 2 51.96 Quite High
Targeted Disruption 29 43.28 Quite Low
Weight Loss 12 28.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the PI3K pathway was also involved in the cytokine-mediated reduction of Sp1/Sp3 binding to its recognition sequence in the LPL gene, the effect of pre-treatment of the cells with three different concentrations of the PI3K inhibitor LY294002 on the IFN-?
Regulation (effect) of LPL gene associated with cytokine
1) Confidence 0.26 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.05
target genes involved in triglycerides (TG) synthesis such as lipoprotein lipase (Lpl), phosphoenolpyruvate carboxykinase (PEPCK) and CD36 was significantly upregulated in ?
Regulation (target) of lipoprotein lipase
2) Confidence 0.25 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
Consistent with the Kit-induced hepatic phenotype, interference with lipase function induces type I hyperlipoproteinemia in human (OMIN238600) and more severe hyperchylomicronemia affecting post-natal viability in Lpl mutant mice [37] or in Combined Lipase deficiency (Cld), which alters both Lpl and Hepatic lipase (Lipc) activities [38-40].
Regulation (alters) of Lpl associated with hyperlipidemia
3) Confidence 0.23 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.22 Pain Relevance 0
The mechanisms, by which exercise and reduced weight increase HDL-C likely involves enchanced lipoprotein lipase (LL) activity, increased RCT, and increased levels of pre-?
Regulation (involves) of lipoprotein lipase associated with disorder of lipid metabolism
4) Confidence 0.10 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.01 Pain Relevance 0.04
Angiopoietin-like 4 (ANGPTL4) is a circulating lipoprotein lipase (LPL) inhibitor that controls triglyceride deposition into adipocytes and has been reported to be regulated by gut microbes.


Regulation (regulated) of LPL in gut associated with obesity
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948012 Disease Relevance 0.18 Pain Relevance 0.04
Our results open the intriguing possibility that modifying LPL activity through ANGPTL4, central to fat storage regulation, by manipulating the gut flora could be one important mechanism by which various interventions may modulate body fat storage.


Regulation (regulation) of LPL in gut
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948012 Disease Relevance 0.09 Pain Relevance 0.03
The other is to modulate the serum cholesterol level by targeting genes such as the lipoprotein lipase gene [62] and the apolipoprotein regulating genes AI, AII, and CII [63].
Regulation (targeting) of lipoprotein lipase gene in CII associated with disorder of lipid metabolism
7) Confidence 0.02 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.21 Pain Relevance 0

General Comments

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