INT211548

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Context Info
Confidence 0.76
First Reported 2007
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 29
Disease Relevance 12.83
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lpin1) endoplasmic reticulum (Lpin1) nucleus (Lpin1)
lipid metabolic process (Lpin1) cytoplasm (Lpin1)
Anatomy Link Frequency
retinas 9
bile 2
liver 1
striatum 1
brain 1
Lpin1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 10 100.00 Very High Very High Very High
Central nervous system 342 98.92 Very High Very High Very High
glial activation 38 98.76 Very High Very High Very High
peripheral neuropathy 19 81.44 Quite High
Spinal cord 76 49.44 Quite Low
anesthesia 29 5.00 Very Low Very Low Very Low
isoflurane 20 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
ischemia 19 5.00 Very Low Very Low Very Low
alcohol 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 809 100.00 Very High Very High Very High
Lipodystrophy 20 100.00 Very High Very High Very High
Injury 912 99.66 Very High Very High Very High
Retinal Perforations 38 99.32 Very High Very High Very High
Wound Healing 475 98.36 Very High Very High Very High
Fatty Liver 48 97.52 Very High Very High Very High
Diabetes Mellitus 19 97.52 Very High Very High Very High
Shock 57 97.44 Very High Very High Very High
Disease 38 95.88 Very High Very High Very High
Ganglion Cysts 95 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was further supported by the expression analysis of genes such as VldlR and Lpin1 that start to be expressed at 2.5 dpp (this study).
Gene_expression (expressed) of Lpin1
1) Confidence 0.76 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.17 Pain Relevance 0
In Kit mutants, a defective hepatic metabolism, with the abnormal low expression of VldlR and Lpin1, leads to the maintenance of this "transient steatosis".
Gene_expression (expression) of Lpin1
2) Confidence 0.76 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.12 Pain Relevance 0
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Spec (determined) Gene_expression (expression) of Lpin1 in bile associated with bile and lipodystrophy
3) Confidence 0.76 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.17 Pain Relevance 0.05
This was further supported by the expression analysis of genes such as VldlR and Lpin1 that start to be expressed at 2.5 dpp (this study).
Gene_expression (expression) of Lpin1
4) Confidence 0.76 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.17 Pain Relevance 0
In forebrain, the expression variability of genes Lpin1, Id2, Sox11, and AL024210 mapped within the locus.
Gene_expression (expression) of Lpin1 in forebrain
5) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.39 Pain Relevance 0.05
Our meta-analyses of publicly available data revealed that Lpin1, Id2, and Sox11 were differentially expressed during retinal development and trauma.
Gene_expression (expressed) of Lpin1 associated with injury
6) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.49 Pain Relevance 0.03
Gene expression patterns in the developing retina suggest that Lpin1 is expressed during the time of Muller cell birth and differentiation (P8-P14) (Retina Developmental Gene Expression, probe set 98892_at (RetDevExpression, accessed January 2005); Mouse Retina SAGE Library, Mm.153625 (RetSAGE, Accessed October 2005)).
Gene_expression (expressed) of Lpin1 in retina
7) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.76 Pain Relevance 0.07
In normal and injured retinas, Id2 and Lpin1 were more highly expressed in strains carrying the C57BL6 allele than in strains carrying the DBA/2J allele.
Gene_expression (expressed) of Lpin1 in retinas associated with sprains and strains
8) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.70 Pain Relevance 0.07
Using publicly available data on mouse retinal development (Dorrell et al. 2004), we determined that Lpin1, Id2, and Sox11 were expressed by the developing retina and had well defined patterns of expression (Fig. 3E; note that AL024210 levels were below detectable thresholds).
Gene_expression (expressed) of Lpin1 in retina
9) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.32 Pain Relevance 0.05
Lpin1, Id2, and Sox11 were expressed in reactive glia of optic nerve heads (Yang et al. 2004) and diabetic retinas (Gerhardinger et al. 2005).
Gene_expression (expressed) of Lpin1 in retinas associated with diabetes mellitus
10) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.48 Pain Relevance 0.04
Genetic variability can explain the expression variability and strong linkage of Lpin1, Sox11, AL024210, and Id2 to their gene locations (cis-eQTLs).
Gene_expression (expression) of Lpin1
11) Confidence 0.75 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.19 Pain Relevance 0.08
Lpin1 reduced expression is presumably a major event leading to the abnormal metabolism of lipid in KitSco5/Sco5 mice.
Gene_expression (expression) of Lpin1
12) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.25 Pain Relevance 0
Indeed, Lpin1 loss-of-function induces steatosis and juvenile lethality in the "fatty liver dystrophy" (fld) mice, a model of human lipodystrophy [27,42].
Gene_expression (loss) of Lpin1 in liver associated with fatty liver and lipodystrophy
13) Confidence 0.66 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.27 Pain Relevance 0
Higher levels of Id2 and Lpin1 correlated with higher levels of neuronal marker Thy1 and heat-shock-like crystallin genes (Cryab, Cryba4, and Crygd).
Gene_expression (levels) of Lpin1 in neuronal associated with shock
14) Confidence 0.65 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.71 Pain Relevance 0.07
Similarly, KIT could cooperate with members of the lipoprotein receptors family, such as VLDLR, or could control the expression of Lpin1, regulating the hepatic triglyceride metabolism and oxidative phosphorylation through its key position in the PPARa/PGC-1a regulatory pathway [44].
Gene_expression (expression) of Lpin1
15) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.12 Pain Relevance 0
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Spec (determined) Gene_expression (expression) of Lipin 1 in bile associated with bile and lipodystrophy
16) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.17 Pain Relevance 0.05
In models of retinal tear and toxic injury, higher Id2 and Lpin1 expression levels and fold changes were also observed in BXD38 retinas relative to DBA/2J retinas (Supplementary Fig. 2C and 2D).
Gene_expression (expression) of Lpin1 in retinas associated with retinal perforations and injury
17) Confidence 0.58 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.80 Pain Relevance 0
To investigate the role of chromosome 12 locus, we compared the wound-healing response of retinas that expresses high levels of Id2/Lpin1 (strains with the C57BL/6 allele) to retinas expressing low levels of Id2/Lpin1 (strains with the DBA/2J allele) (Fig. 5).
Gene_expression (expresses) of Lpin1 in retinas associated with injury and sprains and strains
18) Confidence 0.58 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.85 Pain Relevance 0
Moreover, the C57BL/6 allele (high Id2/Lpin1 expresser) displayed greater changes in glial cells for the protective STAT3 signaling and for the negative regulator of glial proliferation CD81.


Gene_expression (expresser) of Lpin1 in glial cells
19) Confidence 0.58 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.55 Pain Relevance 0.07
Based on expression data from injured BXD retinas, the expression patterns for Id2 and Lpin1 correlated positively with the C57BL/6 allele.
Gene_expression (expression) of Lpin1 in retinas
20) Confidence 0.58 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.70 Pain Relevance 0

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