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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Scarb1) plasma membrane (Scarb1) cytoplasm (Scarb1)
Anatomy Link Frequency
alveolar macrophages 1
bile 1
Scarb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 2 99.12 Very High Very High Very High
cytokine 8 96.72 Very High Very High Very High
metalloproteinase 6 78.56 Quite High
agonist 1 29.16 Quite Low
Inflammatory response 2 12.08 Low Low
Inflammation 20 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 146 99.28 Very High Very High Very High
Lipodystrophy 2 95.40 Very High Very High Very High
Mycobacterial Infection 51 79.48 Quite High
Bordatella Infection 1 78.64 Quite High
Hematological Disease 6 59.48 Quite High
INFLAMMATION 28 50.00 Quite Low
Infection 20 50.00 Quite Low
Sprains And Strains 6 47.76 Quite Low
Adhesions 18 42.44 Quite Low
Atherosclerosis 11 27.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To decipher the molecular basis of Kit-dependent steatosis, we determined the expression profiles of key genes involved in lipid hepatic metabolism: such as apoliproteins (Apoa1, ApoB), lipoprotein receptors (LdlR, VldlR, Scarb1, Lrp1), lipase (Lipc, LipH, Lpl) and others implicated in hepatic lipidogenesis (Scap, Srebf1, Srebf2), lipid secretion (Pltp, Mttp, Abca1), bile acid synthesis (Cyp8b1, Cyp7a1), lipid transport (Slc10a1, Abcb11, Abcb1a, Abcc2) and a lipodystrophy gene, Lipin 1 (Lpin1), encoding a phosphatidate phosphatase enzyme with transcription activity [26-28].
Localization (secretion) of Scarb1 in bile associated with bile and lipodystrophy
1) Confidence 0.60 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.15 Pain Relevance 0.05
At the same time, when resident alveolar macrophages differentiate by cytokine stimulation, they increase the expression of surface receptors and show a higher affinity to bind mycobacteria [27], therefore maybe completely render any role of SR-B1 redundant.

Localization (redundant) of SR-B1 in alveolar macrophages associated with cytokine
2) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794535 Disease Relevance 0.21 Pain Relevance 0.05
Consistent with this idea is the observation that HDL maintains the appropriate cellular localization of eNOS by replenishing endothelial cellular membranes with cholesteryl esters in an SR-BI–dependent fashion (Uittenbogaard et al 2000).
Localization (localization) of SR-BI associated with disorder of lipid metabolism
3) Confidence 0.33 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 0.90 Pain Relevance 0.07

General Comments

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