INT21156

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Context Info
Confidence 0.36
First Reported 1986
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 7.95
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PLXNA3) plasma membrane (PLXNA3) intracellular (PLXNA3)
PLXNA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 4 99.82 Very High Very High Very High
Cannabinoid 5 99.76 Very High Very High Very High
alcohol 405 99.52 Very High Very High Very High
imagery 9 98.08 Very High Very High Very High
cannabis 4 87.20 High High
Neurotransmitter 1 83.40 Quite High
Opioid 1 82.68 Quite High
Dopamine 14 82.24 Quite High
Endocannabinoid 2 81.84 Quite High
Bioavailability 1 80.20 Quite High
Disease Link Frequency Relevance Heat
Stress 384 100.00 Very High Very High Very High
Reprotox - General 1 3 99.56 Very High Very High Very High
Death 3 99.44 Very High Very High Very High
Alcohol Intoxication 48 96.56 Very High Very High Very High
Cognitive Disorder 22 96.48 Very High Very High Very High
Disease 15 95.92 Very High Very High Very High
Alopecia 1 94.80 High High
Infection 181 94.02 High High
Drug Dependence 11 90.20 High High
Schizophrenia 1 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Approximately 95% to 98% of estradiol is bound loosely to albumin or tightly to sex hormone binding globulin, the major binding protein.
sex Binding (bound) of
1) Confidence 0.36 Published 1995 Journal J Clin Pharmacol Section Abstract Doc Link 8530713 Disease Relevance 0.08 Pain Relevance 0.09
Gender specific differences have been observed in both human and animal studies implying sex hormone and related factors may interact with cannabinoids in neurodevelopment.
sex Binding (interact) of associated with cannabinoid
2) Confidence 0.36 Published 2006 Journal Hum Psychopharmacol Section Abstract Doc Link 16783814 Disease Relevance 0.85 Pain Relevance 0.56
Dehydroepiandrosterone sulfate decreased only towards the end of treatment, while estrone, sex hormone binding globulin, and PRL remained unchanged.
sex Binding (binding) of
3) Confidence 0.35 Published 1990 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2166069 Disease Relevance 0.60 Pain Relevance 0
Similarly, dehydroepiandrosterone sulfate, sex hormone binding globulin, and gonadotrophin levels were unaltered after 6 months of treatment.
sex Binding (binding) of
4) Confidence 0.35 Published 1986 Journal Cancer Res. Section Abstract Doc Link 2942241 Disease Relevance 0.55 Pain Relevance 0.08
Diet and sex-hormone binding globulin, dysmenorrhea, and premenstrual symptoms.
sex Binding (binding) of associated with dismenorea
5) Confidence 0.35 Published 2000 Journal Obstet Gynecol Section Title Doc Link 10674588 Disease Relevance 0.19 Pain Relevance 0.39
Serum sex hormone binding globulin was elevated.
sex Binding (binding) of
6) Confidence 0.35 Published 2003 Journal South. Med. J. Section Abstract Doc Link 14513996 Disease Relevance 0.99 Pain Relevance 0.12
Later in life he experimented with drugs and sex.
sex Binding (experimented) of
7) Confidence 0.08 Published 2005 Journal BMC Public Health Section Body Doc Link PMC1310629 Disease Relevance 0.25 Pain Relevance 0
One promising indication that these sex differences in the effects of stress on risky decision making generalize across stressors and decision contexts is that, like in our study, Preston et al. [4] found that social stress made females more conservative but males more risky on a gambling task (although their sex by stress interaction did not achieve statistical significance).
sex Binding (interaction) of associated with stress
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698212 Disease Relevance 1.04 Pain Relevance 0.19
The interaction between sex and stress condition for the number of balloon pumps did not reach significance after controlling for cortisol change, F(1,40)?
sex Binding (interaction) of associated with stress
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698212 Disease Relevance 0.46 Pain Relevance 0
However, this main effect was qualified by an interaction of stress condition and sex, F(1,41)?
sex Binding (interaction) of associated with stress
10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698212 Disease Relevance 0.71 Pain Relevance 0
An ANOVA examining the average number of pumps on non-explosion trials for these participants revealed an interaction of stress condition and sex, F(1,37)?
sex Binding (interaction) of associated with stress
11) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698212 Disease Relevance 0.71 Pain Relevance 0
Individuals genotyped as 7R+ were significantly more likely to reported having ever engaged in promiscuous sex (i.e., a one-night stand).
sex Spec (likely) Binding (engaged) of
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994774 Disease Relevance 0.12 Pain Relevance 0.06
There was one significant interaction between drug injection and having sex when high on drugs or alcohol (p = 0.015).
sex Binding (interaction) of associated with alcohol
13) Confidence 0.03 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0 Pain Relevance 0.31
In analysis restricted to IDUs, reporting multiple sex partners was independently associated with methamphetamine use and reporting sex when high on drugs or alcohol.
sex Binding (associated) of associated with alcohol
14) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0.07 Pain Relevance 0.28
Logistic regression was employed to assess bivariate associations of the three selected sexual risk behavior outcomes (multiple sex partners, unprotected sex, and a positive test for a non-viral STI) with the demographic and substance use related factors.
sex Binding (associations) of
15) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0.14 Pain Relevance 0.11
In analysis limited to IDUs, unprotected sex was associated with being married, using methamphetamine and having sex when high on drugs or alcohol.
sex Binding (associated) of associated with alcohol
16) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0 Pain Relevance 0.38
This study investigated the prevalence of sexual risk behaviors, non-viral STIs and substance use patterns between IDUs and non-IDUs who have IDU sex partners and tested three hypotheses: (1) that the prevalence of STIs and the frequency of sexual risk behaviors would be greater among IDUs than non-IDUs, (2) that substance use measures that were correlated with sexual risks would be different among IDUs and non-IDUs, and (3) that both global patterns of substance use and substance use in sexual contexts would be associated with unprotected sex with casual partners among both IDUs as well as among non-IDUs.
sex Binding (associated) of associated with infection
17) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0.98 Pain Relevance 0
Similar to other studies of non-IDUs, the major risk factor associated with unprotected sex was the participant's general (i.e. monthly) pattern of risky drinking and not being drunk at the time of sex [46].
sex Binding (associated) of associated with alcohol intoxication
18) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0.10 Pain Relevance 0.20
In analysis of 140 sexual partnerships reported by 65 non-IDUs, unprotected sex was associated with older age.


sex Binding (associated) of
19) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0 Pain Relevance 0.18
Among non-IDUs, unprotected sex was independently associated with risky alcohol use.
sex Binding (associated) of associated with alcohol
20) Confidence 0.02 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2988741 Disease Relevance 0 Pain Relevance 0.35

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