INT211571

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.30
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pik3r1, Kit) nucleus (Pik3r1, Kit) plasma membrane (Pik3r1, Kit)
kinase activity (Pik3r1, Kit) cell differentiation (Kit) intracellular (Pik3r1)
Anatomy Link Frequency
testis 2
Pik3r1 (Mus musculus)
Kit (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hematological Disease 6 88.44 High High
Stress 1 83.84 Quite High
Cancer 2 71.96 Quite High
Targeted Disruption 1 54.08 Quite High
Anaemia 5 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Hyperlipidemia 3 5.00 Very Low Very Low Very Low
Lipodystrophy 2 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Sco1, Sco5 and Whc1 displayed essentially normal gametogenesis suggesting that the M623, V667 in the ATP binding site and the F809 in the activation loop domain are not as important as the Y719 bound by the phosphatidylinositol 3'-kinase (PI3K) that is essential for Kit function in testis [20].
PI3K Positive_regulation (essential) of Gene_expression (function) of Kit in testis
1) Confidence 0.30 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1940254 Disease Relevance 0.30 Pain Relevance 0

General Comments

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