INT211581

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.49
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Pms2) DNA binding (Pms2)
Anatomy Link Frequency
germline 1
Pms2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 77.12 Quite High
palliative 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 67 99.76 Very High Very High Very High
Microsatellite Instability 15 95.80 Very High Very High Very High
Cancer 60 95.24 Very High Very High Very High
Colon Cancer 5 86.60 High High
Targeted Disruption 5 78.08 Quite High
Aging 12 76.40 Quite High
Aneuploidy 3 75.80 Quite High
Genomic Instability 5 73.52 Quite High
Carcinoma 9 67.88 Quite High
Endometroid Carcinoma 12 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Study of this model revealed that the mutability of the repeat is age-dependent and activity of the mismatch repair protein Msh3 (usually found associated in the Msh2/Msh3 MutS?
mismatch Binding (activity) of
1) Confidence 0.32 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1940261 Disease Relevance 0.27 Pain Relevance 0.04
HNPCC patients with endometrial cancers have an inherited germline mutation in MLH-1, MSH-2, MSH-6, or PMS-2, but endometrial cancer only develops after the instauration of a deletion or mutation in the contralateral MLH-1, MSH-2, MSH-6, or PMS-2 allele.
PMS-2 Binding (mutation) of in germline associated with endometrial cancer
2) Confidence 0.14 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 2.22 Pain Relevance 0

General Comments

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