INT211585

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.63
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dmpk) mitochondrion (Dmpk) endoplasmic reticulum (Dmpk)
plasma membrane (Dmpk) nucleus (Dmpk) kinase activity (Dmpk)
Anatomy Link Frequency
acinar cells 2
heart 2
Dmpk (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 6 68.64 Quite High
fibrosis 1 18.48 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
spastic colon 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 5 99.60 Very High Very High Very High
Targeted Disruption 104 98.08 Very High Very High Very High
Arrhythmias 2 Under Development 18 96.36 Very High Very High Very High
Polyploidy 5 95.80 Very High Very High Very High
Heart Disease 4 91.92 High High
Muscle Disease 4 90.08 High High
Hypopituitarism 35 88.72 High High
Congenital Anomalies 42 86.16 High High
Cv General 2 Under Development 4 83.32 Quite High
Arrhythmia Under Development 13 75.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the one hand, the activity of the ribonuclease downregulates the mutant DMPK transcript, which removes a toxic RNA from the cell and may contribute to the reduction of DMPK expression levels.
Negative_regulation (reduction) of Gene_expression (expression) of DMPK
1) Confidence 0.47 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
The functional implications of a reduction in DMPK expression were genetically tested with the generation of knockout mice.
Negative_regulation (reduction) of Gene_expression (expression) of DMPK associated with targeted disruption
2) Confidence 0.41 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.33 Pain Relevance 0.03
Expansion appears also transcription independent, as the Dmpk gene is expressed at very low levels in hepatocytes and appears fully repressed in acinar cells [[21], own findings, unpublished].
Spec (appears) Negative_regulation (repressed) of Gene_expression (expressed) of Dmpk gene in acinar cells
3) Confidence 0.41 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1940261 Disease Relevance 0.25 Pain Relevance 0
One might assume that, by analogy to these observations, the aggregation of the mutant DMPK mRNA in nuclei is likely mediated by a reduced processing of the mutant DMPK mRNA.
Negative_regulation (reduced) of Gene_expression (processing) of mutant DMPK mRNA
4) Confidence 0.32 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Such reduction of the mutant DMPK mRNA export could be because of diminished capacity of the modification enzymes to process the mutant DMPK mRNA.
Negative_regulation (reduction) of Gene_expression (export) of mutant DMPK mRNA
5) Confidence 0.32 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Identification of the mutant DMPK in aggregated form in cytoplasm of DM1 cells suggests that, like in nuclei, cytoplasmic processing of mutant DMPK mRNA might be also reduced by the CUG repeat tract.
Negative_regulation (reduced) of Gene_expression (processing) of mutant DMPK mRNA
6) Confidence 0.32 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
As reduction in Dmpk and Six5 levels does not completely recapitulate the severity of DM1 cardiac pathology, these data suggest that toxic effects associated with the expression of CUG repeats play a prominent role in the etiology of DM1 heart disease.
Negative_regulation (reduction) of Gene_expression (levels) of Dmpk in heart associated with heart disease
7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597774 Disease Relevance 0.85 Pain Relevance 0
in the chromatin, were dramatically reduced after three weeks of mutant DMPK RNA expression.
Negative_regulation (reduced) of Gene_expression (expression) of DMPK
8) Confidence 0.30 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.19 Pain Relevance 0

General Comments

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