INT211586

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.11
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DMPK) mitochondrion (DMPK) plasma membrane (DMPK)
nucleus (DMPK) cytoplasm (DMPK)
Anatomy Link Frequency
myoblasts 1
muscle 1
frontal cortex 1
DMPK (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 140 99.60 Very High Very High Very High
Inflammation 10 84.00 Quite High
GABAergic 20 77.56 Quite High
gABA 18 33.44 Quite Low
Kinase C 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
interneuron 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 3 99.76 Very High Very High Very High
Urological Neuroanatomy 2 99.04 Very High Very High Very High
Hypopituitarism 30 98.76 Very High Very High Very High
Cataract 9 98.56 Very High Very High Very High
Arrhythmias 2 Under Development 3 97.84 Very High Very High Very High
Frailty 64 93.16 High High
Disease 78 92.16 High High
Movement Disorders 4 91.20 High High
INFLAMMATION 8 84.00 Quite High
Targeted Disruption 61 83.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Contrary to DM1, patients with DM2 are less affected based on MRI findings.
Regulation (affected) of DM1 associated with imagery
1) Confidence 0.31 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2940021 Disease Relevance 0.41 Pain Relevance 0.27
Consistent with the involvement of MBNL proteins in the RNA gain of function mechanism, Mbnl1 knockdown mice [60] showed DM1-like phenotypes including iridescent cataracts, myotonia and missplicing of muscle transcripts that had been reported altered in DM1 patients such as IR and CLC-1 pre-mRNA [61, 62]. muscleblind mutant embryos similarly showed altered expression of muscle transcript isoforms from the Drosophila ZASP homologue and alpha-actinin genes [63].
Regulation (altered) of DM1 in muscle associated with hypopituitarism and cataract
2) Confidence 0.27 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0.38 Pain Relevance 0
The DM1 mutation is an expansion of a CTG•CAG repeat in the 3' UTR of the DMPK gene on chromosome 19.
Regulation (expansion) of DM1
3) Confidence 0.17 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1940261 Disease Relevance 0.90 Pain Relevance 0
[93] and Mef2A [70] in differentiating cells by interacting with translation initiation factor eIF2, the mechanism by which translation was inefficient in DM1 muscle cells was not fully understood, in particular after confirming that the levels of CUG-BP1 mRNA did not show any significant change in DM1 muscle cells when compared to normal myoblasts [94].
Regulation (change) of DM1 in myoblasts
4) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2694559 Disease Relevance 0 Pain Relevance 0
Total RNA extracted from adult SCA8, DM1 and control and from 26-week fetal frontal cortex was examined by qRT-PCR using primers to exons 1 and 2.
Regulation (control) of DM1 in frontal cortex associated with urological neuroanatomy
5) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.17 Pain Relevance 0.04
Similar to the dysregulation of other genes in DM1 (CLCN-1, IR) [5], the expression of CUGexp but not CAGexp transcripts [37] triggers a shift in the ratios of alternatively spliced GABT4 transcripts that resembles those found during fetal development.
Regulation (dysregulation) of DM1
6) Confidence 0.08 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719092 Disease Relevance 0.25 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox