INT2116

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Context Info
Confidence 0.36
First Reported 1978
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 10.67
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VSX1) cellular_component (VSX1)
Anatomy Link Frequency
maxilla 2
lymphocyte 2
blood 1
B-lymphocyte 1
tooth 1
VSX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 107 100.00 Very High Very High Very High
opioid receptor 2 99.84 Very High Very High Very High
antagonist 3 99.44 Very High Very High Very High
narcan 2 98.72 Very High Very High Very High
antidepressant 21 95.76 Very High Very High Very High
cytokine 8 93.96 High High
analgesia 2 93.44 High High
Analgesic 2 93.20 High High
Kinase C 3 86.36 High High
tetrodotoxin 1 80.24 Quite High
Disease Link Frequency Relevance Heat
Depression 100 100.00 Very High Very High Very High
Post-partum Depression 14 100.00 Very High Very High Very High
Hemorrhage 23 99.80 Very High Very High Very High
Periodontitis 303 99.40 Very High Very High Very High
Nicotine Addiction 319 99.08 Very High Very High Very High
Clinical Trials And Case Reports 42 96.56 Very High Very High Very High
Hereditary Corneal Dystrophies 2 93.96 High High
Chronic Periodontitis 71 93.52 High High
Penetrating Wounds 1 91.16 High High
Bordatella Infection 2 89.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduction of PPD and bleeding index after healing were similar in test and control areas.
Negative_regulation (Reduction) of PPD associated with hemorrhage
1) Confidence 0.36 Published 2002 Journal Swed Dent J Section Abstract Doc Link 12462872 Disease Relevance 0.43 Pain Relevance 0.17
However, D’Aiuto et al. observed more favorable PPD reduction at interproximal sites, whereas this study observed the contrary.
Negative_regulation (reduction) of PPD
2) Confidence 0.32 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.25 Pain Relevance 0
This is quite similar to the results of this study regarding PAL-V gain and PPD reduction after SRP.
Negative_regulation (reduction) of PPD
3) Confidence 0.32 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.55 Pain Relevance 0
This might explain more favorable PPD reduction at interproximal sites without adjusting for baseline PPD.
Spec (might) Negative_regulation (reduction) of PPD
4) Confidence 0.32 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.24 Pain Relevance 0
Current smoking was generally associated with less favorable PPD reduction and RAL-V gain in all models.
Negative_regulation (reduction) of PPD associated with nicotine addiction
5) Confidence 0.32 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.60 Pain Relevance 0
As mentioned above CHED also needs to be distinguished from PPCD.



Negative_regulation (distinguished) of PPCD
6) Confidence 0.28 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.69 Pain Relevance 0
This compound inhibited PPD stimulated human lymphocyte proliferation and this inhibition was reversed by opioid receptor antagonist, naloxone.
Negative_regulation (inhibited) of PPD in lymphocyte associated with antagonist, narcan and opioid receptor
7) Confidence 0.27 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095165 Disease Relevance 0.09 Pain Relevance 0.38
This compound inhibited PPD stimulated human lymphocyte proliferation and this inhibition was reversed by opioid receptor antagonist, naloxone.
Negative_regulation (reversed) of PPD in lymphocyte associated with antagonist, narcan and opioid receptor
8) Confidence 0.27 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 12095165 Disease Relevance 0.09 Pain Relevance 0.39
For baseline PPD 4–5 mm they report PAL-V gains of 0.31 mm and PPD reduction of 1.1 mm after non-surgical as well as 0.21 mm and 1.6 mm after surgical therapy.
Negative_regulation (reduction) of PPD
9) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.45 Pain Relevance 0
Taking radiographic parameters into consideration, current smoking resulted in less favorable and baseline PPD in better RAL-V gain and PPD reduction, respectively (Tables 10 and 11).
Negative_regulation (reduction) of PPD associated with nicotine addiction
10) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.47 Pain Relevance 0
At 6 months, PPD reduction and RAL-V gain were significantly greater at sites receiving SRP and AF as compared to untreated sites (p?
Negative_regulation (reduction) of PPD
11) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Abstract Doc Link PMC2134843 Disease Relevance 0.24 Pain Relevance 0
Generally, baseline PPD was related to better PPD reduction and RAL-V gain (p?
Negative_regulation (reduction) of PPD
12) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.59 Pain Relevance 0
However, calculation of a mean value, e.g., for PPD reduction, across a patient in fact levels out tooth-related characteristics.
Negative_regulation (reduction) of PPD in tooth
13) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.34 Pain Relevance 0.06
PPD reduction was poorer in current smokers, at premolars, in the maxilla, and at interproximal sites (Table 9).
Negative_regulation (reduction) of PPD in maxilla associated with nicotine addiction
14) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.35 Pain Relevance 0
Our PPD reductions and RAL-V gains achieved 6 months after therapy confirm data by a meta-analysis on nonsurgical vs surgical periodontal therapy that reports PPD reduction of 1.07 mm and vertical attachment (PAL-V) gains of 0.6 mm at sites with baseline PPD 4–6 mm 6 months after SRP.
Negative_regulation (reduction) of PPD
15) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.15 Pain Relevance 0
However, PPD reductions 6 months after AF for mean baseline PPD of 5.4 mm were 1.0 mm which is less than the meta analysis lists for baseline PPD 4–6 mm: PPD reduction 1.37 mm.
Negative_regulation (reductions) of PPD associated with clinical trials and case reports
16) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.18 Pain Relevance 0
Whereas baseline PPD was related to better PPD reduction and RAL-V gain (p?
Negative_regulation (reduction) of PPD
17) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.41 Pain Relevance 0
It is interesting to note that the diagnosis of aggressive periodontitis affected RAL-V gains but not PPD reduction.
Negative_regulation (reduction) of PPD associated with periodontitis
18) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.72 Pain Relevance 0
The diagnosis of aggressive periodontitis was associated with less favorable RAL-V gains, whereas it was not kept in the models to explain PPD reduction.
Negative_regulation (reduction) of PPD associated with periodontitis
19) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.79 Pain Relevance 0
0.0114) were associated with better PPD reduction (Table 9).


Negative_regulation (reduction) of PPD
20) Confidence 0.24 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.42 Pain Relevance 0

General Comments

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