INT21160

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Context Info
Confidence 0.64
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 19.37
Pain Relevance 12.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
leukocytes 6
neutrophils 4
platelet 3
coronary artery 3
blood 2
Sell (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 159 100.00 Very High Very High Very High
cINOD 28 99.92 Very High Very High Very High
metalloproteinase 1 99.24 Very High Very High Very High
Morphine 30 98.78 Very High Very High Very High
Thermal hyperalgesia 1 98.16 Very High Very High Very High
Bile 1 97.86 Very High Very High Very High
Angina 68 97.84 Very High Very High Very High
chemokine 22 97.32 Very High Very High Very High
Inflammatory response 12 96.16 Very High Very High Very High
rheumatoid arthritis 91 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 168 100.00 Very High Very High Very High
Adhesions 113 100.00 Very High Very High Very High
Coronary Artery Disease 40 99.16 Very High Very High Very High
Hypoxia 2 98.90 Very High Very High Very High
Stress 20 98.72 Very High Very High Very High
Cardiovascular Disease 22 98.68 Very High Very High Very High
Hyperalgesia 13 98.16 Very High Very High Very High
Syndrome 8 97.92 Very High Very High Very High
Cv General 3 Under Development 70 97.84 Very High Very High Very High
Myocardial Infarction 48 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of L-selectin expression in neutrophils by nonsteroidal anti-inflammatory drugs: role of intracellular ATP concentration.
Gene_expression (expression) of L-selectin in neutrophils associated with inflammation and cinod
1) Confidence 0.64 Published 2000 Journal Blood Section Title Doc Link 11071659 Disease Relevance 0.38 Pain Relevance 0.76
However, the KD-IX-73-4, an inhibitor of L-selectin proteolysis was able to block the effect of NSAIDs on L-selectin expression.
Gene_expression (expression) of L-selectin associated with cinod
2) Confidence 0.64 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.28 Pain Relevance 0.85
In vitro studies revealed that binding of purified platelet membranes to control neutrophils caused a dose-dependent increase in CD11b surface expression, a decrease in surface L-selectin, and the release of superoxide anions.
Gene_expression (expression) of L-selectin in platelet
3) Confidence 0.59 Published 1996 Journal Circulation Section Body Doc Link 8822975 Disease Relevance 0.05 Pain Relevance 0
Systemic neutrophil activation was found in patients with unstable angina compared with those with stable angina assessed by cell surface CD11b expression and shedding of L-selectin (115.6 +/- 10.3 versus 74.0 +/- 6.3 anti-CD11b mean fluorescence intensity, P = .002; 49.8 +/- 6.0 versus 72.1 +/- 4.0 anti-L-selectin mean fluorescence intensity, P = .006).
Gene_expression (expression) of L-selectin in neutrophil
4) Confidence 0.59 Published 1996 Journal Circulation Section Body Doc Link 8822975 Disease Relevance 0.07 Pain Relevance 0
Neither treatment tested increased the venular shear rate or modified the venular diameters, number of circulating leukocytes, and L-selectin expression on granulocytes.
Gene_expression (expression) of L-selectin in granulocytes
5) Confidence 0.54 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16044031 Disease Relevance 0.55 Pain Relevance 0.55
Venular shear rate, venular diameters, number of circulating leukocytes, and post-leukotriene B4 expression of l-selectin and CD11/CD18 integrin in leukocytes were unaffected by any treatment.
Gene_expression (expression) of l-selectin in leukocytes
6) Confidence 0.45 Published 2004 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14716214 Disease Relevance 0.55 Pain Relevance 0.58
Stimulation of leukocytes resulted in a rapid downregulation of surface L-selectin expression, measured by flowcytometry, similar to the suppressed expression of L-selectin found on leukocytes from patients with coronary artery disease.
Gene_expression (expression) of L-selectin in coronary artery associated with coronary artery disease
7) Confidence 0.15 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.16 Pain Relevance 0.59
This inflammatory process results in downregulation of leukocyte expression of L-selectin and thus lower circulating sL-selectin levels.
Gene_expression (expression) of L-selectin in leukocyte associated with inflammation
8) Confidence 0.15 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.00 Pain Relevance 0.44
To examine the mechanism of reduction in sL-selectin levels and L-selectin expression on leukocytes, leukocytes from the control group were stimulated in vitro.
Gene_expression (expression) of L-selectin in leukocytes
9) Confidence 0.15 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.39 Pain Relevance 0.75
L-selectin expression was observed to be depressed in patients with severe angina compared with that in members of the control group.
Gene_expression (expression) of L-selectin associated with angina
10) Confidence 0.15 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.63 Pain Relevance 0.75
Stimulation of leukocytes resulted in a rapid downregulation of surface L-selectin expression, measured by flowcytometry, similar to the suppressed expression of L-selectin found on leukocytes from patients with coronary artery disease.
Gene_expression (expression) of L-selectin in coronary artery associated with coronary artery disease
11) Confidence 0.15 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.19 Pain Relevance 0.61
METHODS: We studied changes in adhesion molecule expression of platelets (GPIIb/IIIa), neutrophils--CD18, CD11b and L-selectin--and monocytes (CD14) after interaction with active lesions of patients with stable angina subjected to PTCA and patients with unstable angina (UA).
Gene_expression (expression) of L-selectin in monocytes
12) Confidence 0.15 Published 2005 Journal Int. J. Cardiol. Section Body Doc Link 15771923 Disease Relevance 0.19 Pain Relevance 0
In group 1A, the L-selectin decreased significantly at second blood samplings (2.3 +/- 1.2 mg/L, p <0.001 vs baseline), whereas in group 1B there was no significant change in L-selectin (3.9 +/- 1.0 mg/L, p = NS vs baseline).
Gene_expression (decreased) of L-selectin in blood
13) Confidence 0.14 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.22 Pain Relevance 0.27
In this study we characterize the contribution of intercellular adhesion molecules (ICAM-1) and L-selectin in patients with different coronary artery disease syndromes.
Gene_expression (contribution) of L-selectin in coronary artery associated with coronary artery disease, syndrome and adhesions
14) Confidence 0.13 Published 1996 Journal Am. Heart J. Section Abstract Doc Link 8701848 Disease Relevance 1.60 Pain Relevance 0.47
The serum levels of ICAM-1 and L-selectin were both significantly higher in groups 1A and 1B than in group 2.
Gene_expression (levels) of L-selectin
15) Confidence 0.12 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.24 Pain Relevance 0.25
To investigate the effects of morphine on neutrophil and endothelial activation, we measured serum levels of intercellular adhesion molecule-1 (ICAM-1), L-selectin, and neutrophil endopeptidase 24.11 (NEP) in 38 patients with acute myocardial infarction (group 1) and 16 control subjects (group 2).
Gene_expression (levels) of L-selectin in neutrophil associated with myocardial infarction, adhesions and morphine
16) Confidence 0.12 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.27 Pain Relevance 0.25
Shear stress, hypoxia and stasis activate the marginated leukocytes to shed L-selectin from their surface and express integrins, matrix metalloproteinase 9, elastase, lactoferrin and free radicals.
Gene_expression (express) of L-selectin in leukocytes associated with stress, hypoxia and metalloproteinase
17) Confidence 0.07 Published 2007 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 17726258 Disease Relevance 1.02 Pain Relevance 0.54
The proportion of immunocytes expressing L-selectin was increased in inflamed lymph nodes and subcutaneous paw tissue.
Gene_expression (expressing) of L-selectin in paw
18) Confidence 0.07 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.57 Pain Relevance 0.46
P-selectin and PECAM-1 were constitutively expressed on endothelia of noninflamed lymph nodes and subcutaneous tissue and were upregulated in inflammation. beta-endorphin positive cells expressed L-selectin in lymph nodes and subcutaneous tissue.
Gene_expression (expressed) of L-selectin in endothelia associated with inflammation
19) Confidence 0.07 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 10900350 Disease Relevance 0.57 Pain Relevance 0.46
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Gene_expression (expression) of L-selectin in platelet associated with inflammation and adhesions
20) Confidence 0.06 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.71 Pain Relevance 0.88

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