INT211608

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.80
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Nucb2) endoplasmic reticulum (Nucb2) nucleus (Nucb2)
DNA binding (Nucb2) cytoplasm (Nucb2)
Nucb2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 108 99.00 Very High Very High Very High
tolerance 3 95.04 Very High Very High Very High
antagonist 12 56.88 Quite High
amygdala 8 56.64 Quite High
Opioid 4 6.32 Low Low
metalloproteinase 6 5.80 Low Low
medulla 27 5.00 Very Low Very Low Very Low
Bile 16 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
potassium channel 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 115 99.68 Very High Very High Very High
Hypertrophy 1 97.60 Very High Very High Very High
Disorder Of Lipid Metabolism 5 96.28 Very High Very High Very High
Insulin Resistance 5 94.88 High High
Targeted Disruption 40 93.68 High High
Diabetes Mellitus 38 80.92 Quite High
Fatty Liver 6 78.32 Quite High
Anorexia 14 76.64 Quite High
Body Weight 60 74.28 Quite High
Weight Gain 15 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
reduction in circulating INS, TG, and NEFA levels.
Negative_regulation (reduction) of NEFA
1) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC1940322 Disease Relevance 0.44 Pain Relevance 0.45
Compared to untreated db/db mice, NEFA levels in the rosiglitazone-treated db/db mice decreased dramatically.
Negative_regulation (decreased) of NEFA
2) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2481284 Disease Relevance 1.01 Pain Relevance 0.05
Serum NEFA levels were significantly decreased, although serum glucose and triglyceride levels were essentially unchanged.
Negative_regulation (decreased) of NEFA
3) Confidence 0.06 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 1.21 Pain Relevance 0
Nesfatin-1 concentrations are reduced in the PVN with fasting.
Negative_regulation (reduced) of Nesfatin-1
4) Confidence 0.06 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.13 Pain Relevance 0.06

General Comments

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