INT21161

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Context Info
Confidence 0.58
First Reported 1990
Last Reported 2011
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 8.64
Pain Relevance 6.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Sell) plasma membrane (Sell)
Anatomy Link Frequency
neutrophil 2
joint 1
plasma 1
blood 1
leukocytes 1
Sell (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 88 99.92 Very High Very High Very High
Angina 27 99.92 Very High Very High Very High
cINOD 32 99.84 Very High Very High Very High
Pain 48 99.08 Very High Very High Very High
nociceptor 2 98.94 Very High Very High Very High
Inflammatory response 8 98.72 Very High Very High Very High
metalloproteinase 1 98.00 Very High Very High Very High
ischemia 4 96.04 Very High Very High Very High
depression 6 95.68 Very High Very High Very High
analgesia 56 94.84 High High
Disease Link Frequency Relevance Heat
Adhesions 37 100.00 Very High Very High Very High
Cv General 3 Under Development 18 99.92 Very High Very High Very High
Arthritis 3 99.92 Very High Very High Very High
INFLAMMATION 105 99.84 Very High Very High Very High
Hypoxia 2 99.00 Very High Very High Very High
Stress 21 98.82 Very High Very High Very High
Schizophrenia 17 98.16 Very High Very High Very High
Coronary Artery Disease 9 98.12 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.16 Very High Very High Very High
Injury 4 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In agreement with this finding, azide plus 2-deoxy-D-glucose, 2 metabolic blockers, also induced a rapid L-selectin shedding (65% +/- 8%) without affecting the neutrophil viability, activation, or expression level of other surface molecules with soluble isoforms such as CD16 and CD59.
Positive_regulation (induced) of L-selectin in neutrophil
1) Confidence 0.58 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.24 Pain Relevance 0.83
Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils.
Positive_regulation (inducing) of L-selectin in joint associated with pain, inflammation and arthritis
2) Confidence 0.46 Published 1999 Journal Nat. Med. Section Title Doc Link 10470085 Disease Relevance 1.67 Pain Relevance 0.86
Our group has recently described that several nonsteroidal anti-inflammatory drugs (NSAIDs) are able to induce both in vivo and in vitro the shedding of L-selectin in neutrophils through an unknown mechanism.
Positive_regulation (induce) of L-selectin in neutrophils associated with inflammation and cinod
3) Confidence 0.39 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.36 Pain Relevance 0.65
In this work, we have studied potential mechanisms involved in the shedding of L-selectin induced by NSAIDs.
Positive_regulation (induced) of L-selectin associated with cinod
4) Confidence 0.39 Published 2000 Journal Blood Section Abstract Doc Link 11071659 Disease Relevance 0.34 Pain Relevance 0.75
HYPOTHESIS: The purpose of this study was to determine whether soluble E-selectin, P-selectin and L-selectin levels are increased in patients with unstable angina (UA).
Spec (whether) Positive_regulation (increased) of L-selectin
5) Confidence 0.34 Published 2001 Journal Int. J. Cardiol. Section Body Doc Link 11259814 Disease Relevance 0.09 Pain Relevance 0
Alterations in circulating intercellular adhesion molecule-1 and L-selectin: further evidence for chronic inflammation in ischemic heart disease.
Positive_regulation (circulating) of L-selectin in heart associated with coronary artery disease, inflammation and adhesions
6) Confidence 0.10 Published 1996 Journal Am. Heart J. Section Title Doc Link 8701848 Disease Relevance 1.68 Pain Relevance 0.61
During attacks of angina pectoris an increase in the plasma levels of the soluble adhesion molecules, ICAM-1 and L-selectin, was noted, possibly reflecting activation of neutrophils and endothelial cells during myocardial ischemia.
Positive_regulation (increase) of L-selectin in plasma associated with angina, coronary artery disease, ischemia and adhesions
7) Confidence 0.07 Published 1998 Journal Heart Vessels Section Abstract Doc Link 10442400 Disease Relevance 1.26 Pain Relevance 1.03
Shear stress, hypoxia and stasis activate the marginated leukocytes to shed L-selectin from their surface and express integrins, matrix metalloproteinase 9, elastase, lactoferrin and free radicals.
Positive_regulation (shed) of L-selectin in leukocytes associated with stress, hypoxia and metalloproteinase
8) Confidence 0.06 Published 2007 Journal Clin. Hemorheol. Microcirc. Section Abstract Doc Link 17726258 Disease Relevance 1.02 Pain Relevance 0.48
Other adhesion molecules, including P-selectin, platelet-endothelial adhesion molecule-1 (PECAM-1), and L-selectin, are also upregulated in inflammation, and these increased expression levels correlate with increased END levels (Mousa et al 2000).
Positive_regulation (upregulated) of L-selectin in platelet associated with inflammation and adhesions
9) Confidence 0.06 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.70 Pain Relevance 0.86
In eosinophils, indomethacin induced chemotaxis, CD11b up-regulation, respiratory burst, and L-selectin shedding but did not cause up-regulation of CD63 expression.
Positive_regulation (up-regulation) of L-selectin in respiratory
10) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11980903 Disease Relevance 0.15 Pain Relevance 0.13
By reducing the blood plasma vasopressin content, myelopid promotes increase in the corticoliberin content in the hypothalamus and increase of 11-OCS biosynthesis in the adrenals.
Positive_regulation (increase) of 11-OCS in blood
11) Confidence 0.02 Published 1990 Journal Patol Fiziol Eksp Ter Section Abstract Doc Link 2166271 Disease Relevance 0 Pain Relevance 0.13
Iwata et al. [29] found increased levels of serum soluble L-selectin, but not sP-selectin, in 23 unmedicated patients with schizophrenia when compared with patients with major depression (N = 17; P = 0.02) or healthy subjects (N = 36; P = 0.005).
Positive_regulation (increased) of L-selectin associated with depression and schizophrenia
12) Confidence 0.01 Published 2011 Journal BMC Psychiatry Section Body Doc Link PMC3022806 Disease Relevance 1.12 Pain Relevance 0.25

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