INT211636

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.16
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oxtr) signal transducer activity (Oxtr)
Oxtr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 49 99.88 Very High Very High Very High
Inflammation 3 99.84 Very High Very High Very High
Inflammatory stimuli 1 84.64 Quite High
Dismenorea 5 72.72 Quite High
imagery 6 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.84 Very High Very High Very High
Targeted Disruption 59 93.56 High High
Myocardial Infarction 3 91.52 High High
Embryonal Carcinoma 69 85.04 High High
Dysmenorrhea 5 72.72 Quite High
Increased Venous Pressure Under Development 3 62.00 Quite High
Natriuresis 9 34.28 Quite Low
Hyperplasia 3 31.76 Quite Low
Pre-term Labor 9 23.96 Low Low
Premature Birth 6 19.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specificity of this reaction was examined by inhibition by OT antagonists (OTA) and OTR suppression by specific small interfering RNA (siRNA) and similar condition was investigated for V1aR.


Negative_regulation (suppression) of OTR associated with antagonist
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.09 Pain Relevance 0.10
Replacement of Ile 3 by other amino acid residues causes a significant decrease of affinity for OTR [36].
Negative_regulation (decrease) of OTR
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0 Pain Relevance 0
Already known is a positive effect of OT/OTR in inflammation [41], [42], [43].
Negative_regulation (effect) of OTR associated with inflammation
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.61 Pain Relevance 0.18
results in delayed luteolysis, high progesterone levels, decreased levels of oxytocin receptor and connexin-43 (Muglia, unpublished results) on d19.0 (half-day prior to normal delivery) [10,16,17].
Negative_regulation (decreased) of oxytocin receptor
4) Confidence 0.12 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

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