INT211657

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Context Info
Confidence 0.53
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.48
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Arg1) cytoplasm (Arg1)
Anatomy Link Frequency
situs 1
erythrocyte 1
T-cell 1
Arg1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 1 91.76 High High
diclofenac 190 82.48 Quite High
Bioavailability 2 77.12 Quite High
ketamine 2 49.16 Quite Low
chemokine 4 26.96 Quite Low
Inflammation 18 5.00 Very Low Very Low Very Low
COX-2 inhibitor 12 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 253 99.86 Very High Very High Very High
Hemolysis 16 99.38 Very High Very High Very High
Adhesions 6 95.28 Very High Very High Very High
Reperfusion Injury 1 92.52 High High
Cv Unclassified Under Development 1 91.76 High High
Increased Venous Pressure Under Development 9 90.80 High High
Targeted Disruption 63 87.44 High High
Thrombophilia 6 79.68 Quite High
Stress 2 78.52 Quite High
Injury 6 72.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To measure arginase activity, cells were washed with PBS and dissolved in 0.1% TritonX100 in water for 30 min at room temperature.


Localization (measure) of arginase
1) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 0.51 Pain Relevance 0.03
The authors proposed that high COX-2 activity of tumor cells releases PGE2, which activates arginase in MDSC and leads to extracellular arginine depletion and subsequent T-cell dysfunction.
Localization (releases) of arginase in T-cell associated with cancer
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939880 Disease Relevance 1.04 Pain Relevance 0.04
In situ hybridization of arginase, Tnfrsf9 and Tnni2 d18.0 looked similar to d19.0 in situs (data not shown).
Localization (hybridization) of arginase in situs
3) Confidence 0.43 Published 2007 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1941732 Disease Relevance 0.53 Pain Relevance 0
During hemolysis, breakdown of the erythrocyte releases hemoglobin and the enzyme arginase into circulation.
Localization (releases) of arginase in erythrocyte associated with hemolysis
4) Confidence 0.16 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 1.40 Pain Relevance 0.12

General Comments

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