INT21168

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Context Info
Confidence 0.53
First Reported 1986
Last Reported 2008
Negated 1
Speculated 2
Reported most in Body
Documents 14
Total Number 17
Disease Relevance 1.99
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
neutrophils 5
respiratory 1
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 28 100.00 Very High Very High Very High
addiction 41 96.72 Very High Very High Very High
Inflammation 138 93.32 High High
TRP channel 26 92.40 High High
Morphine 2 89.40 High High
agonist 52 89.16 High High
aspirin 4 87.12 High High
Inflammatory response 26 81.16 Quite High
Potency 13 80.08 Quite High
Bioavailability 4 61.72 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 183 100.00 Very High Very High Very High
Hyperplasia 2 99.08 Very High Very High Very High
Neointima 2 97.68 Very High Very High Very High
Vasculitis 6 96.32 Very High Very High Very High
Targeted Disruption 39 92.64 High High
Stress 46 91.88 High High
Atherosclerosis 18 89.88 High High
Hypertension 24 83.00 Quite High
Increased Venous Pressure Under Development 4 68.16 Quite High
Cardiovascular Disease 6 52.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apocynin treatment of the collared arteries did not affect Nox2 mRNA
Neg (not) Regulation (affect) of Nox2
1) Confidence 0.53 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.45 Pain Relevance 0.03
Targeting NADPH-oxidase via
Regulation (Targeting) of NADPH-oxidase
2) Confidence 0.53 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.62 Pain Relevance 0
We conclude that NADPH oxidase activity can be adversely affected by the circulating levels of common antibiotics and sedatives.
Regulation (affected) of NADPH oxidase
3) Confidence 0.41 Published 1986 Journal Arch Surg Section Abstract Doc Link 3942501 Disease Relevance 0 Pain Relevance 0.16
Similar conclusions are provided with the imidazole antimycotic, itraconazole: Interference with SOCE into human neutrophils does not appear to affect the NADPH oxidase [188].
Spec (appear) Regulation (affect) of NADPH oxidase in neutrophils
4) Confidence 0.39 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.23 Pain Relevance 0.24
This review summarizes the present knowledge about Ca2+ influx-regulated NADPH oxidase activity induced by external stimuli in neutrophils.


Regulation (regulated) of NADPH oxidase in neutrophils
5) Confidence 0.39 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
PKC, a phospholipid-dependent family of serine-threonine protein kinases, acts in multiple signal transduction pathways including the regulation of the NADPH oxidase.
Regulation (regulation) of NADPH oxidase
6) Confidence 0.39 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
This suggests that NADPH oxidase regulation requires a second signal, Ca2+-independent pathway, acting in synergy with Ca2+ influx from SOCE [3].
Regulation (regulation) of NADPH oxidase
7) Confidence 0.39 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Taken together, these results provide strong evidence for the involvement of two separate Ca2+ signaling pathways in NADPH oxidase regulation but no direct correlation between non-SOCE or SOCE, and NADPH oxidase has yet been formally established.
Regulation (regulation) of NADPH oxidase
8) Confidence 0.39 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.03
Ca2+-regulated NADPH oxidase during phagocytosis
Regulation (regulated) of NADPH oxidase
9) Confidence 0.29 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Further, lysophosphatidic acid has stimulatory effects on NADPH oxidase in a concentration-dependent manner.
Regulation (effects) of NADPH oxidase
10) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.04
This apparent link between SOCE and NADPH oxidase is supported by data of Lee et al. [106], relating a modulation of Ca2+ entry and attenuation of NADPH oxidase activity in neutrophils that have been subjected to MRS1845.
Regulation (modulation) of NADPH oxidase in neutrophils
11) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.10
Conventional PKCs are pointed out as participants for regulating NADPH oxidase in neutrophils.
Regulation (regulating) of NADPH oxidase in neutrophils
12) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.09 Pain Relevance 0.04
Several targets of Ca2+ ions involved in NADPH oxidase control are resolved, such as PKC?
Regulation (control) of NADPH oxidase
13) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.07 Pain Relevance 0.15
Regulation of chemoattractant-induced NADPH oxidase by Ca2+ influx
Regulation (Regulation) of NADPH oxidase
14) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0.05
This review emphasizes the role of calcium influx in the control of the NADPH oxidase and summarizes the current knowledge of pathways mediating this extracellular calcium entry in neutrophils.
Regulation (control) of NADPH oxidase in neutrophils
15) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Abstract Doc Link PMC2567897 Disease Relevance 0.17 Pain Relevance 0.04
Store-operated calcium entry (SOCE), whereby the depletion of intracellular stores induces extracellular calcium influx, is known to be a crucial element of NADPH oxidase regulation.
Regulation (regulation) of NADPH oxidase
16) Confidence 0.17 Published 2008 Journal J Leukoc Biol Section Abstract Doc Link PMC2567897 Disease Relevance 0.19 Pain Relevance 0.05
The effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the respiratory burst oxidase (NADPH oxidase, EC 1.6.99.6) from human neutrophils in both whole cell and fully soluble (cell-free) systems were investigated.
Spec (investigated) Regulation (effects) of NADPH oxidase in respiratory associated with inflammation and cinod
17) Confidence 0.12 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 2166517 Disease Relevance 0.17 Pain Relevance 0.52

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