INT211685

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cntnap1) cell adhesion (Cntnap1) cytoskeleton organization (Cntnap1)
Anatomy Link Frequency
nodes 1
Cntnap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
unmyelinated 12 98.68 Very High Very High Very High
Nav1.6 160 98.62 Very High Very High Very High
sodium channel 50 84.84 Quite High
withdrawal 4 58.64 Quite High
Pain 18 16.64 Low Low
Action potential 6 9.12 Low Low
Neuropathic pain 12 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Demyelination 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 6 63.08 Quite High
Bites And Stings 2 58.88 Quite High
Demyelinating Disease 22 35.04 Quite Low
Pain 20 16.64 Low Low
Disease 4 5.76 Low Low
Neuropathic Pain 16 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Hyperalgesia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the dense Nav1.6 staining seen at nodes, selective labeling of fibers that lacked an association with caspr, and that most likely represent unmyelinated fibers, was absent in the IONs of both control and lesioned subjects.
caspr Binding (association) of in nodes associated with unmyelinated and nav1.6
1) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.77
The caspr staining was typically intense and selective within the paranodal region and associated with sharp demarcation borders.
caspr Binding (associated) of
2) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0.18 Pain Relevance 0.66

General Comments

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