INT211690

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.03
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cntnap1) cell adhesion (Cntnap1) cytoskeleton organization (Cntnap1)
Anatomy Link Frequency
nodes 5
Schwann cell 2
Cntnap1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.6 720 99.90 Very High Very High Very High
sodium channel 225 95.88 Very High Very High Very High
Inflammation 54 86.08 High High
Pain 81 84.76 Quite High
Neuropathic pain 54 84.72 Quite High
withdrawal 18 80.16 Quite High
Lasting pain 9 66.44 Quite High
unmyelinated 54 59.56 Quite High
Action potential 27 30.64 Quite Low
Neuronal excitability 9 19.04 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 72 86.08 High High
Pain 90 84.76 Quite High
Neuropathic Pain 72 84.72 Quite High
Peripheral Arterial Disease 27 84.60 Quite High
Bites And Stings 9 80.40 Quite High
Demyelinating Disease 99 56.56 Quite High
Disease 18 27.28 Quite Low
Nervous System Injury 27 25.00 Low Low
Injury 45 5.00 Very Low Very Low Very Low
Hyperalgesia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantification of Nav1.6 and caspr immunofluorescence in single fibers
Gene_expression (immunofluorescence) of caspr associated with nav1.6
1) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.55
The average intensity of paranodal caspr staining was determined from an average intensity z-projection of the caspr-alone z-series and included measurements of caspr staining on both sides of 7–17 typical nodes that were randomly selected from each z-series (53 nodes were each evaluated in lesioned IONs and normal IONs).
Gene_expression (projection) of caspr in nodes
2) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.50
The area of caspr staining on each side of the node where intensity was measured was identified as a "region of interest" or "ROI" in a merged maximum-intensity z-projection of the matching Nav1.6 combined with caspr z-series.
Gene_expression (projection) of caspr in node associated with nav1.6
3) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.47
Typical nodes of Ranvier were identified as the gap seen between the paranodal staining of caspr with the Nav1.6 staining at nodes in normal IONs assuming a prominent disc-like appearance (Figs. 1A and 2A).
Gene_expression (staining) of caspr in nodes associated with nav1.6
4) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0.19 Pain Relevance 0.59
The average intensity of paranodal caspr staining was determined from an average intensity z-projection of the caspr-alone z-series and included measurements of caspr staining on both sides of 7–17 typical nodes that were randomly selected from each z-series (53 nodes were each evaluated in lesioned IONs and normal IONs).
Gene_expression (projection) of caspr in nodes
5) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.51
The common relationship of caspr with Nav1.6 was also altered in some accumulations and included the presence of "heminodes" where caspr staining was located on only one side of a contiguous Nav1.6 accumulation and "split nodes" where two distinct NaCh accumulations were separated by a gap in the same fiber and with each accumulation flanked on one side by caspr (Fig. 2B).
Gene_expression (staining) of caspr in nodes associated with sodium channel and nav1.6
6) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.78
Qualitative observations of Nav1.6 and caspr staining patterns and relationships in normal vs. lesioned IONs
Gene_expression (patterns) of caspr associated with nav1.6
7) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0.30 Pain Relevance 0.51
The augmentation of Nav1.6 may result from an alteration in axon-Schwann cell signaling mechanisms as suggested by changes in caspr expression.
Gene_expression (expression) of caspr in Schwann cell associated with nav1.6
8) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.74
The augmentation of Nav1.6 may result from an alteration in axon-Schwann cell signaling mechanisms as suggested by changes in caspr expression.
Gene_expression (expression) of caspr in Schwann cell associated with nav1.6
9) Confidence 0.05 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0.54 Pain Relevance 0.86

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