INT211694

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 3.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cntnap1) cell adhesion (Cntnap1) cytoskeleton organization (Cntnap1)
Anatomy Link Frequency
nodes 2
Cntnap1 (Rattus norvegicus)
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.6 320 100.00 Very High Very High Very High
sodium channel 100 75.00 Quite High
Pain 36 39.16 Quite Low
Inflammation 24 36.56 Quite Low
unmyelinated 24 32.92 Quite Low
Neuropathic pain 24 5.00 Very Low Very Low Very Low
Demyelination 16 5.00 Very Low Very Low Very Low
Peripheral nervous system 12 5.00 Very Low Very Low Very Low
Action potential 12 5.00 Very Low Very Low Very Low
Multiple sclerosis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 40 39.16 Quite Low
INFLAMMATION 32 36.56 Quite Low
Nervous System Injury 12 33.12 Quite Low
Demyelinating Disease 44 30.64 Quite Low
Neuropathic Pain 32 7.12 Low Low
Injury 20 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 12 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low
Bites And Stings 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Typical nodes were identified and defined by the presence of a dense Nav1.6 accumulation flanked on both sides by the paranodal staining of caspr as seen in the Nav1.6 combined with caspr z-series.
caspr Binding (combined) of Nav1.6 in nodes associated with nav1.6
1) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.78
Typical nodes were identified and defined by the presence of a dense Nav1.6 accumulation flanked on both sides by the paranodal staining of caspr as seen in the Nav1.6 combined with caspr z-series.
caspr Binding (staining) of Nav1.6 in nodes associated with nav1.6
2) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.78
In the lesioned IONs, Nav1.6 accumulations were also seen in association with altered caspr-relationships, such as heminodes.


caspr Binding (association) of Nav1.6 associated with nav1.6
3) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.95
In addition, the analysis of typical nodesalso showed that the average nodal gap axial length as measured by the number of pixels in the caspr-demarcated gap that is occupied by Nav1.6, was significantly greater (p < 0.01) in lesioned IONs than in normal IONs (7.72 +/- 0.29 (SEM) vs. 3.95 +/- 0.13 (SEM); Fig. 3D).
caspr Binding (occupied) of Nav1.6 associated with nav1.6
4) Confidence 0.04 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1941742 Disease Relevance 0 Pain Relevance 0.62

General Comments

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