INT2117

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Context Info
Confidence 0.30
First Reported 1977
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 3.38
Pain Relevance 3.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (VSX1) cellular_component (VSX1)
Anatomy Link Frequency
lymphocytes 2
substantia nigra 1
Acb 1
corneal endothelium 1
spinal cord 1
VSX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 24 100.00 Very High Very High Very High
Kinase C 9 99.92 Very High Very High Very High
Ventral tegmentum 2 99.88 Very High Very High Very High
Spinal cord 3 99.60 Very High Very High Very High
Substantia nigra 2 99.34 Very High Very High Very High
Pain 11 99.00 Very High Very High Very High
antagonist 5 98.48 Very High Very High Very High
Nucleus accumbens 22 97.60 Very High Very High Very High
opioid receptor 1 93.84 High High
spinal dorsal horn 2 88.00 High High
Disease Link Frequency Relevance Heat
Depression 24 100.00 Very High Very High Very High
Diverticulum 19 100.00 Very High Very High Very High
Pain 5 99.00 Very High Very High Very High
Corneal Edema 6 97.60 Very High Very High Very High
Targeted Disruption 1 96.94 Very High Very High Very High
Nicotine Addiction 46 96.24 Very High Very High Very High
Pancreatitis 17 95.80 Very High Very High Very High
Hemorrhage 8 94.96 High High
Chronic Periodontitis 11 94.16 High High
Bordatella Infection 6 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the recognition of patchy epithelial-like alterations of the corneal endothelium in the genetically heterogeneous PPCD and the absence of these changes in CHED, which has marked corneal edema it remains controversial as to whether these disorders of posterior cornea are distinct or involve a common mechanistic process.
Regulation (alterations) of PPCD in corneal endothelium associated with corneal edema
1) Confidence 0.30 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2695576 Disease Relevance 0.17 Pain Relevance 0
In contrast, all accumbens nucleus neurons projecting to the ventral mesencephalic regions including the substantia nigra and ventral tegmental area were immunopositive for PPD but not for PPE.
Neg (not) Regulation (immunopositive) of PPD in substantia nigra associated with ventral tegmentum, nucleus accumbens and substantia nigra
2) Confidence 0.15 Published 2003 Journal Neuroscience Section Abstract Doc Link 12895518 Disease Relevance 0 Pain Relevance 0.45
The main outcome variable for the comparison of the therapeutic effects of no further therapy, SRP, or AF was chosen to be the change of PPD.
Regulation (change) of PPD
3) Confidence 0.15 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0 Pain Relevance 0
To identify factors influencing the treatment result, change of RAL-V and PPD were analyzed by application of a multilevel regression model using backward selection.
Spec (analyzed) Regulation (change) of PPD
4) Confidence 0.15 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.15 Pain Relevance 0
Models were fitted for the dependent variables (1) RAL-V change after 6 months and (2) PPD change after 6 months including the following independent variables: (1) clinical: age, sex, actual smoking (yes/no), pack years, diagnosis (aggressive/chronic periodontitis), jaw (maxilla/mandible), site (interproximal/buccal or oral), tooth type (anterior/premolar), therapy (none/SRP/AF), and PlI and GI at baseline, (2) radiographic: interproximal bone loss in percent, infrabony defect, and double contour of the root.
Regulation (change) of PPD in tooth associated with chronic periodontitis and nicotine addiction
5) Confidence 0.15 Published 2007 Journal Clin Oral Investig Section Body Doc Link PMC2134843 Disease Relevance 0.19 Pain Relevance 0
Reduction in the PPD and gain in the CAL are the most important clinical outcomes of regenerative therapy.33 It is well documented that a gain in the CAL after any type of regenerative and conventional periodontal treatment is dependent on the initial PPD; that is, the deeper the initial PPD, the greater is the PPD reduction and clinical attachment gain.8 In addition, the depth of the intrabony defect is the determining factor for the maximal possible attachment gain.34 In this way, a deeper intrabony defect may be related to a greater gain in the CAL.8 There were no differences between the treatment groups in terms of the initial PPD and intrabony defect depth.
Spec (may) Regulation (dependent) of PPD
6) Confidence 0.13 Published 2010 Journal European Journal of Dentistry Section Body Doc Link PMC2948748 Disease Relevance 0 Pain Relevance 0
The mitogen and PPD responses in these groups showed throughout a fall in lymphocyte transformation.
Regulation (responses) of PPD in lymphocyte
7) Confidence 0.08 Published 1978 Journal Ann. Clin. Res. Section Abstract Doc Link 354470 Disease Relevance 0.07 Pain Relevance 0.08
The premedication increased the proportion and absolute number of surface immunoglobulin-positive (B) lymphocytes in the peripheral blood and reduced the PHA and PPD responses in whole blood cultures.
Regulation (responses) of PPD in lymphocytes
8) Confidence 0.05 Published 1977 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 605766 Disease Relevance 0 Pain Relevance 0.16
In contrast, all accumbens nucleus neurons projecting to the ventral mesencephalic regions including the substantia nigra and ventral tegmental area were immunopositive for PPD but not for PPE.
Neg (not) Regulation (immunopositive) of PPD in ventral associated with ventral tegmentum, nucleus accumbens and substantia nigra
9) Confidence 0.05 Published 2003 Journal Neuroscience Section Abstract Doc Link 12895518 Disease Relevance 0 Pain Relevance 0.45
A previous knockout study revealed the critical role of downstream regulatory element antagonist modulator (DREAM) in pain processing in the spinal cord by transcriptional regulation of prodynorphin (PPD) gene.
Regulation (regulation) of PPD in spinal cord associated with targeted disruption, pain, antagonist and spinal cord
10) Confidence 0.04 Published 2007 Journal Neurochem. Res. Section Abstract Doc Link 17562172 Disease Relevance 0.35 Pain Relevance 0.50
Double-immunofluorescence analysis revealed that PPD, PPE and PPTB immunoreactivities were shown in 69%, 19% and 14% of PPTA-immunoreactive neurons, respectively, in the Acb core region, and in 92%, 7% and 25% of PPTA-immunoreactive neurons, respectively, in the Acb shell region.
Regulation (immunoreactivities) of PPD in Acb associated with nucleus accumbens
11) Confidence 0.03 Published 2002 Journal Neuroscience Section Abstract Doc Link 12220564 Disease Relevance 0 Pain Relevance 0.38
The aim of this study was to examine epidermal changes in PPD using the more sensitive method of transmission electron microscopy.
Spec (examine) Regulation (changes) of PPD
12) Confidence 0.03 Published 2008 Journal Clinics Section Body Doc Link PMC2664235 Disease Relevance 0.24 Pain Relevance 0
In addition, endoscopic papillitis and PPD were not influenced by the sphincterotomy-induced complications.
Neg (not) Regulation (influenced) of PPD associated with diverticulum
13) Confidence 0.01 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2880265 Disease Relevance 0.61 Pain Relevance 0.06
Even though protein kinase C activation caused a partial reduction in the presynaptic effect of baclofen, its lack of effect on PPD makes a significant role for protein kinase C in modulation of PPD unlikely.
Regulation (modulation) of PPD associated with kinase c and depression
14) Confidence 0.01 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7884461 Disease Relevance 0.42 Pain Relevance 0.35
PDA had no effect on PPD. 3.
Neg (no) Regulation (effect) of PPD associated with depression
15) Confidence 0.01 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7884461 Disease Relevance 0.59 Pain Relevance 0.47
Ba2+ dramatically reduced postsynaptic GABAB responses; it had no effect on PPD.
Neg (no) Regulation (effect) of PPD associated with depression
16) Confidence 0.01 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7884461 Disease Relevance 0.59 Pain Relevance 0.47
Biologic samples (peripheral blood, buccal swab, saliva) were collected from six members of the pedigree affected with CDB, one member affected with posterior polymorphous dystrophy (PPCD), three unaffected members, and five individuals of unknown affected status due to their age.
Regulation (affected) of PPCD in posterior
17) Confidence 0.01 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2518171 Disease Relevance 0 Pain Relevance 0

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