INT211701

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 20.64
Pain Relevance 6.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mri1) nucleus (Mri1) cytoplasm (Mri1)
Anatomy Link Frequency
CVO 1
ORNs 1
plaques 1
brain 1
bladder 1
Mri1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 1088 100.00 Very High Very High Very High
Inflammation 164 99.50 Very High Very High Very High
Multiple sclerosis 256 97.20 Very High Very High Very High
fibrosis 5 94.80 High High
Central nervous system 110 93.44 High High
medulla 6 62.44 Quite High
cytokine 47 52.88 Quite High
anesthesia 25 50.76 Quite High
positron emission tomography 18 48.04 Quite Low
Pain 8 42.28 Quite Low
Disease Link Frequency Relevance Heat
Frailty 22 100.00 Very High Very High Very High
Cancer 999 99.64 Very High Very High Very High
INFLAMMATION 168 99.50 Very High Very High Very High
Recurrence 82 99.44 Very High Very High Very High
Breast Cancer 233 99.16 Very High Very High Very High
Targeted Disruption 59 98.80 Very High Very High Very High
Hyperglycemia 55 98.68 Very High Very High Very High
Metastasis 95 98.52 Very High Very High Very High
Amyloid Plaque 28 98.42 Very High Very High Very High
Disease 359 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Optimizing MRI by CHESS reveals prostate lobes
Positive_regulation (Optimizing) of MRI in lobes associated with imagery
1) Confidence 0.34 Published 2007 Journal BMC Urol Section Body Doc Link PMC1945027 Disease Relevance 0 Pain Relevance 0.26
This first experience of MRI-guided FUS for treatment of benign breast tumours was reported by Hynynen et al. in 2001 [39].
Positive_regulation (experience) of MRI-guided associated with breast cancer and imagery
2) Confidence 0.30 Published 2008 Journal Eur Radiol Section Body Doc Link PMC2441491 Disease Relevance 0.89 Pain Relevance 0.17
More recently, Furusawa et al. published improved results of MRI-guided FUS for tumour ablation in a group of 30 breast cancer patients [45].
Positive_regulation (results) of MRI-guided associated with cancer, breast cancer and imagery
3) Confidence 0.30 Published 2008 Journal Eur Radiol Section Body Doc Link PMC2441491 Disease Relevance 1.66 Pain Relevance 0.32
This study also provided evidence than contrast-enhanced MRI was a reliable method to predict the presence of residual tumour after MRI-guided FUS procedure.
Positive_regulation (enhanced) of MRI associated with cancer and imagery
4) Confidence 0.30 Published 2008 Journal Eur Radiol Section Body Doc Link PMC2441491 Disease Relevance 1.24 Pain Relevance 0.39
Further studies will be necessary using earlier stage of tumors, when the Gd contrast leakage is not obviously seen by T1-weighted contrast enhanced MRI, to prove this hypothesis.
Positive_regulation (enhanced) of MRI associated with cancer
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2778127 Disease Relevance 1.25 Pain Relevance 0.10
Visualization of CVO alterations by Gf-enhanced MRI
Positive_regulation (enhanced) of MRI associated with imagery
6) Confidence 0.15 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.64 Pain Relevance 0.40
On magnetic resonance imaging MRI atrophy accumulation becomes apparent.
Positive_regulation (accumulation) of MRI associated with frailty and imagery
7) Confidence 0.12 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 2.31 Pain Relevance 0.88
Assuming a crucial function as "gates to the brain" for immune cells, the visualization of alterations in CVO might become of diagnostic and therapeutic value for the assessment of neuroinflammatory conditions, similar to the detection of BBB impairment by gadopentetate dimeglumine- (Gd-DTPA) enhanced MRI, the current gold standard for the evaluation of disease activity in MS.
Positive_regulation (enhanced) of MRI in CVO associated with multiple sclerosis, disease and imagery
8) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2978145 Disease Relevance 0.98 Pain Relevance 0.40
This is particularly true for invasive approaches such as bi-photon imaging of amyloid plaques or for methods relying on potentially toxic contrast agents such as manganese-enhanced MRI.
Positive_regulation (enhanced) of MRI in plaques associated with imagery and amyloid plaque
9) Confidence 0.09 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952791 Disease Relevance 0.95 Pain Relevance 0.10
In this study, we utilized manganese enhanced MRI (MEMRI) to assess the impact of hyperglycemia on axonal transport rates in ORNs.
Positive_regulation (enhanced) of MRI in ORNs associated with hyperglycemia
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2956689 Disease Relevance 1.14 Pain Relevance 0.13
Anti-inflammatory therapies, which reduce enhancing lesions on MRI and clinical relapses, may delay atrophy and permanent disability accumulation if taken early in disease but they do not prevent the development of either.
Positive_regulation (enhancing) of MRI associated with inflammation, frailty, disease, imagery and recurrence
11) Confidence 0.09 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 2.30 Pain Relevance 0.75
T2-weighted MRI was performed with a multi-spin multi-echo (MSME) sequence of TR?
Positive_regulation (weighted) of MRI associated with imagery
12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746284 Disease Relevance 0.14 Pain Relevance 0.21
In combination with standard MRI techniques (e.g., gadolinium-enhanced MRI, diffusion-weighted MRI, or MR Spectroscopy), our method will allow us to better assess disease activity as related to the presence of therapeutic NSCs.


Positive_regulation (enhanced) of MRI associated with disease and imagery
13) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746284 Disease Relevance 0.62 Pain Relevance 0.20
This was not due to increased number of metastases, but rather a higher concentration of MGd in the brain which allowed for increased sensitivity on MRI.
Positive_regulation (increased) of MRI in brain associated with imagery and metastasis
14) Confidence 0.08 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.90 Pain Relevance 0.16
Dynamic contrast-enhanced MRI and Gd-Cy5.5 for determination of LVF
Positive_regulation (enhanced) of MRI associated with imagery
15) Confidence 0.06 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.69 Pain Relevance 0.31
Dynamic contrast-enhanced MRI (DCE-MRI) images with the use of the contrast agent Gd-Cy5.5 were acquired subsequent to anatomical scans providing sensitive regions of interest (ROI) for calculating T1 values between normal and bladder tumor relaxation times.
Positive_regulation (enhanced) of MRI in bladder associated with bladder cancer and imagery
16) Confidence 0.06 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2241841 Disease Relevance 0.63 Pain Relevance 0.32
An additional exploratory objective is evaluation of lesion size and number after 11 doses of MGd in comparison with standard contrast-enhanced MRI.
Positive_regulation (enhanced) of MRI associated with imagery
17) Confidence 0.06 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2673824 Disease Relevance 0.71 Pain Relevance 0.08
Compared with planar imaging technology (FRI), the FMT data more closely resembled the data generated by iron oxide enhanced MRI, which is a well established tool for the assessment of tumour angiogenesis.
Positive_regulation (enhanced) of MRI associated with cancer and imagery
18) Confidence 0.05 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397521 Disease Relevance 1.12 Pain Relevance 0.40
Our data reveal significant differences in tumour vascularization of the xenografts, as measured in vivo by iron oxide enhanced MRI as well as ex vivo by the BVPD and the level of VEGF expression as surrogate parameters of tumour angiogenesis.
Positive_regulation (enhanced) of MRI associated with cancer and imagery
19) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397521 Disease Relevance 0.74 Pain Relevance 0.20
mol/kg, which is more than two orders of magnitude lower than for gadolinum-enhanced MRI studies.
Positive_regulation (enhanced) of MRI associated with imagery
20) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397521 Disease Relevance 0.71 Pain Relevance 0.54

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