INT211708

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2009
Negated 1
Speculated 4
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 1.92
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
pigmentation 3
Melanocytes 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 389 100.00 Very High Very High Very High
agonist 12 75.64 Quite High
antagonist 19 55.76 Quite High
tolerance 4 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 153 99.26 Very High Very High Very High
Targeted Disruption 5 91.20 High High
Obesity 3 80.72 Quite High
Sprains And Strains 18 78.16 Quite High
Aging 2 76.32 Quite High
Vibrio Infection 3 13.84 Low Low
Shock 4 5.00 Very Low Very Low Very Low
Microphthalmia 2 5.00 Very Low Very Low Very Low
Skin Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether differing amounts of pleiotropy of mutations at these loci affects the evolution of melanism is difficult to say, because mutations in both Agouti and Mc1r may affect traits other than pigmentation.
Spec (may) Regulation (affect) of Agouti in pigmentation associated with melanocortin 1 receptor and freckles
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.32 Pain Relevance 0.43
Melanocytes from lethal yellow and recessive yellow mice: ASIP-like effects on cell morphology and growth
Regulation (effects) of ASIP in Melanocytes
2) Confidence 0.39 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.23 Pain Relevance 0
We also examined the effect of Mc1r genotypes on different Agouti backgrounds (and vice versa) using a categorical measurement of pigmentation.
Spec (examined) Regulation (effect) of Agouti in pigmentation associated with melanocortin 1 receptor
3) Confidence 0.33 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.39
Specifically, we performed parallel expression analyses for Mc1r, Agouti, and beta-Actin (a ubiquitously expressed control gene) mRNAs in the two polionotus subspecies.
Spec (analyses) Regulation (analyses) of Agouti associated with melanocortin 1 receptor
4) Confidence 0.33 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.38
The beach and mainland sequences did not differ by any fixed nonsynonymous mutations, demonstrating that amino acid changes in Agouti are not responsible for the color differences.
Neg (not) Regulation (responsible) of Agouti
5) Confidence 0.33 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.48
To identify whether a coding change in the Agouti gene itself might also contribute to the pigmentation differences between our subspecies, we sequenced Agouti's three translated exons (encoding a 139 amino acid protein) in the six original parents of our cross (Figure S2).
Regulation (change) of Agouti in pigmentation
6) Confidence 0.23 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.57
In natural populations, however, mutations in Mc1r are most commonly associated with melanism [e.g. 12], [14]–[16], although both Agouti and Atrn are larger mutational targets.
Regulation (targets) of Agouti associated with melanocortin 1 receptor and freckles
7) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.73 Pain Relevance 0.69
untranslated regions that are important for temporal and spatial regulation of Agouti and probably any associated cis-regulatory information.
Spec (probably) Regulation (regulation) of Agouti
8) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.64 Pain Relevance 0.22

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