INT211710

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 0.37
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r, a) generation of precursor metabolites and energy (a) signal transduction (Mc1r)
extracellular region (a) plasma membrane (Mc1r) signal transducer activity (Mc1r)
Anatomy Link Frequency
papilla 2
melanocytes 1
pigmentation 1
Mc1r (Mus musculus)
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 342 100.00 Very High Very High Very High
agonist 8 99.36 Very High Very High Very High
adenocard 2 86.08 High High
antagonist 18 41.20 Quite Low
tolerance 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 110 87.76 High High
Targeted Disruption 2 39.36 Quite Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Obesity 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The functions of Atrn and Mgrn are not as well understood, although Atrn is thought to stabilize interactions between Mc1r and Agouti [11].
Mc1r Binding (interactions) of Agouti associated with melanocortin 1 receptor
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.21 Pain Relevance 0.79
It is striking that the interaction between Agouti and Mc1r in these mice is just the reverse of what we would predict from the classical genetics of the laboratory mice.
Mc1r Binding (interaction) of Agouti associated with melanocortin 1 receptor
2) Confidence 0.35 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.96
Because the Mc1r and Agouti proteins interact physically, we tested for epistasis by performing gene interaction analyses (MapManager QTXb [20]).
Mc1r Binding (interact) of Agouti associated with melanocortin 1 receptor
3) Confidence 0.35 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.28
The protein products of three of these genes, Mc1r, Agouti, and Atrn, interact at the surface of pigment-producing cells (melanocytes) and constitute the machinery responsible for “pigment type switching,” the ability of melanocytes to switch between the production of dark brown/black (eumelanin) and light yellow/red pigment (pheomelanin).
Mc1r Binding (interact) of Agouti in melanocytes associated with melanocortin 1 receptor
4) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.16 Pain Relevance 0.49
Agouti, the ligand of Mc1r, is an inverse agonist that, when bound, reduces Mc1r activity (via lowered cAMP signaling) resulting in lighter pigmentation.
Mc1r Binding (ligand) of Agouti in pigmentation associated with melanocortin 1 receptor and agonist
5) Confidence 0.32 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.84
An analysis of the most extreme phenotypes among our F2 progeny shows a striking association between phenotype and the allelic variation (“light” allele derived from the beach parents [L] and “dark” allele derived from the mainland parents [D]) at Agouti and Mc1r.
Mc1r Binding (association) of Agouti associated with melanocortin 1 receptor
6) Confidence 0.26 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40
Such pigment switching is controlled by the interaction of two genes: the melanocortin-1 receptor (Mc1r), which encodes a seven-transmembrane receptor expressed in melanocytes, and its ligand, agouti, whose protein product is secreted from nearby dermal papilla cells and acts to inhibit Mc1r signaling.
Mc1r Binding (ligand) of agouti in papilla associated with melanocortin 1 receptor
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.50
Such pigment switching is controlled by the interaction of two genes: the melanocortin-1 receptor (Mc1r), which encodes a seven-transmembrane receptor expressed in melanocytes, and its ligand, agouti, whose protein product is secreted from nearby dermal papilla cells and acts to inhibit Mc1r signaling.
melanocortin-1 receptor Binding (ligand) of agouti in papilla associated with melanocortin 1 receptor
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.50

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