INT211723

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.85
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rasa1) plasma membrane (Rasa1) embryo development (Rasa1)
cytoplasm (Rasa1)
Anatomy Link Frequency
endothelial cells 1
Rasa1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 93.80 High High
Thalamus 1 88.88 High High
Neurotransmitter 2 86.48 High High
Morphine 91 85.96 High High
Spinal cord 28 82.08 Quite High
medulla 30 81.44 Quite High
agonist 21 78.88 Quite High
cytokine 5 74.16 Quite High
opioid receptor 108 73.88 Quite High
Opioid 42 70.20 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 75 98.04 Very High Very High Very High
Adhesions 2 64.80 Quite High
Arrhythmia Under Development 19 61.92 Quite High
INFLAMMATION 3 58.92 Quite High
Disease 7 49.00 Quite Low
Alzheimer's Dementia 1 47.08 Quite Low
Fibrosis 1 46.44 Quite Low
Heart Rate Under Development 5 36.24 Quite Low
Drug Dependence 3 9.00 Low Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
subunits but precluding their GAP activity on them.
GAP Binding (activity) of
1) Confidence 0.07 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 0.65
On a molecular level, the functional interaction of gap and tight junction is supported by coprecipitation and colocalization of Cx40 and Cx43 with tight junction molecules occludin, claudin-5, and ZO-1 in endothelial cells (25).
gap Binding (interaction) of in endothelial cells
2) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.73 Pain Relevance 0.05
RGS proteins is defined by a conserved 130 amino acid RGS domain, which serve as a GTPase activating protein (GAP) by binding to activated G?
GAP Binding (binding) of
3) Confidence 0.06 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC3017042 Disease Relevance 0.12 Pain Relevance 0.33

General Comments

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