INT211738

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 158 100.00 Very High Very High Very High
opioid receptor 110 100.00 Very High Very High Very High
Delta opioid receptors 21 100.00 Very High Very High Very High
tolerance 56 99.96 Very High Very High Very High
Eae 6 91.44 High High
Potency 2 90.36 High High
Analgesic 18 90.04 High High
antinociception 29 89.68 High High
cva 2 85.40 High High
antagonist 4 82.36 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 42 100.00 Very High Very High Very High
Stress 4 96.00 Very High Very High Very High
Pressure Volume 2 Under Development 4 94.72 High High
Hemorrhage 2 85.40 High High
Nociception 20 72.80 Quite High
Pain 6 61.16 Quite High
Anxiety Disorder 1 51.88 Quite High
Drug Dependence 3 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAG DORs could contribute to morphine tolerance [38–40], behavioral changes
Positive_regulation (morphine) of Phosphorylation (morphine) of PAG associated with tolerance, urological neuroanatomy, delta opioid receptors and morphine
1) Confidence 0.24 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2650089 Disease Relevance 1.20 Pain Relevance 0.98
In contrast to morphine, the initial dose of DAMGO stimulated strong Ser375 phosphorylation and internalization of MORs in PAG neurons.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of PAG in neurons associated with urological neuroanatomy, opioid receptor and morphine
2) Confidence 0.16 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.10 Pain Relevance 1.25

General Comments

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