INT211748

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 1
Pag1 (Mus musculus)
Mors1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 192 100.00 Very High Very High Very High
Morphine 168 100.00 Very High Very High Very High
Periaqueductal grey 20 100.00 Very High Very High Very High
Kinase C 39 95.48 Very High Very High Very High
Potency 2 88.56 High High
Analgesic 37 88.24 High High
Antinociceptive 14 78.16 Quite High
tolerance 71 70.08 Quite High
Opioid 56 61.52 Quite High
Immobilon 3 51.60 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 30 100.00 Very High Very High Very High
Apoptosis 1 5.92 Low Low
Nociception 9 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Inflammatory Pain 2 5.00 Very Low Very Low Very Low
Intractable Pain 2 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to morphine, the initial dose of DAMGO stimulated strong Ser375 phosphorylation and internalization of MORs in PAG neurons.
PAG Binding (internalization) of MORs in neurons associated with urological neuroanatomy, opioid receptor and morphine
1) Confidence 0.07 Published 2007 Journal Mol Pain Section Body Doc Link PMC1947952 Disease Relevance 0.10 Pain Relevance 1.23
Our results indicate that in PAG morphine binding to MORs elicits sustained potentiation of NMDAR function through the activation of the Akt/PKB-nNOS pathway upstream of PKC?
PAG Binding (binding) of MORs associated with kinase c, periaqueductal grey and morphine
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.10 Pain Relevance 1.04

General Comments

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