INT21177

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 2
Speculated 3
Reported most in Abstract
Documents 39
Total Number 45
Disease Relevance 17.50
Pain Relevance 15.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
AtT20 3
visceral 2
nucleus 2
neurons 2
anterior pituitary 2
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 26 100.00 Very High Very High Very High
Enkephalin 8 100.00 Very High Very High Very High
Catecholamine 8 100.00 Very High Very High Very High
dexamethasone 135 99.98 Very High Very High Very High
GABAergic 64 99.84 Very High Very High Very High
Dynorphin 294 99.64 Very High Very High Very High
Dopamine 19 99.62 Very High Very High Very High
Kinase C 188 99.60 Very High Very High Very High
gABA 97 99.56 Very High Very High Very High
narcan 11 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 922 100.00 Very High Very High Very High
Weight Loss 16 99.92 Very High Very High Very High
Nociception 5 99.90 Very High Very High Very High
Body Weight 19 99.72 Very High Very High Very High
Anxiety Disorder 408 99.18 Very High Very High Very High
Hypoglycemia 36 99.08 Very High Very High Very High
Neurodegenerative Disease 13 99.08 Very High Very High Very High
Reprotox - General 1 15 98.04 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

9 97.08 Very High Very High Very High
Neuroblastoma 30 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms by which an activator of cyclic AMP-dependent protein kinase, corticotropin releasing factor (CRF) and the protein kinase C stimulant, phorbol myristate acetate (PMA) regulate the level of intracellular free calcium in the mouse anterior pituitary cell line AtT-20 were examined using the fluorescence probe Quin 2.
Spec (examined) Positive_regulation (activator) of corticotropin releasing factor in anterior pituitary associated with kinase c
1) Confidence 0.70 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2539467 Disease Relevance 0.07 Pain Relevance 0.27
The mechanisms by which an activator of cyclic AMP-dependent protein kinase, corticotropin releasing factor (CRF) and the protein kinase C stimulant, phorbol myristate acetate (PMA) regulate the level of intracellular free calcium in the mouse anterior pituitary cell line AtT-20 were examined using the fluorescence probe Quin 2.
Spec (examined) Positive_regulation (activator) of CRF in anterior pituitary associated with kinase c
2) Confidence 0.70 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2539467 Disease Relevance 0.07 Pain Relevance 0.27
CRH mRNA levels in CP-treated group also increased significantly in the central amygdala as well as the PVN after the CP administration.
Positive_regulation (increased) of CRH mRNA in PVN associated with amygdala
3) Confidence 0.70 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.50 Pain Relevance 0.67
These results suggest that the activation of CRF(1) receptor may play an important role in the elevation of noradrenaline transmission, but not in 5-hydroxytriptamine transmission, in the cerebral cortex, which projects from the locus coeruleus during morphine withdrawal.
Positive_regulation (activation) of CRF in cerebral cortex associated with locus ceruleus, 5ht, noradrenaline, withdrawal, cerebral cortex and morphine
4) Confidence 0.67 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11711043 Disease Relevance 0.23 Pain Relevance 1.39
Furthermore, the ethanolic extract of Curcuma longa significantly reversed the swim stress-induced increases in serum corticotropin-releasing factor and cortisol levels.
Positive_regulation (increases) of serum corticotropin-releasing factor associated with stress
5) Confidence 0.60 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17134862 Disease Relevance 0.42 Pain Relevance 0.44
The possibility that nitric oxide might also be involved was tested using pretreatment with a nitric oxide synthase inhibitor that, however, increased the effect of CRH.
Positive_regulation (increased) of CRH
6) Confidence 0.59 Published 1998 Journal Endocrinology Section Abstract Doc Link 9421440 Disease Relevance 0.47 Pain Relevance 0.23
The CRH gene promoter activity is also enhanced through the cAMP/PKA-dependent pathway.
Positive_regulation (enhanced) of CRH gene
7) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
As with vasopressin, after the removal of the signal peptide, the mature CRH peptide is generated by further processing of proCRH and N-terminal amidation.
Positive_regulation (generated) of CRH peptide
8) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.07
According to this latest paper, when steroid receptor coactivator 1a (SRC-1a) is over-expressed in AtT20 cells, the suppressive effect by dexamethasone on the Fsk-induced CRH gene promoter activity is enhanced, compared with the untransfected cells.
Positive_regulation (enhanced) of CRH gene in AtT20 associated with dexamethasone
9) Confidence 0.57 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.20
mice is not clear, but it may be a consequence of the rewarding effects of dopamine release caused by CRF activation of CRF1-R expressing neurons in the ventral tegmental area [5], [35].
Positive_regulation (activation) of CRF in ventral associated with ventral tegmentum and dopamine
10) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.41 Pain Relevance 0.59
Up-regulation of galanin and corticotropin-releasing hormone mRNAs in the key hypothalamic and amygdaloid nuclei in a mouse model of visceral pain.
Positive_regulation (Up-regulation) of corticotropin-releasing hormone in visceral associated with pain and visceral pain
11) Confidence 0.50 Published 2007 Journal Regul. Pept. Section Title Doc Link 17335920 Disease Relevance 0.45 Pain Relevance 0.78
Collectively, these results point to an important role of CRF and AVP in the regulation of dentate neurogenesis, and suggest that CRF(1) and V(1b) receptor antagonists may affect plasticity changes in the hippocampal formation, as do clinically effective antidepressants.
Positive_regulation (role) of CRF in hippocampal formation associated with antidepressant, antagonist and neurodegenerative disease
12) Confidence 0.50 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 1.11 Pain Relevance 0.41
We therefore tested mice overproducing corticotropin-releasing hormone in a battery of paradigms, studying spontaneous behaviour after a mild stressor, tasks of innate anxiety-like behaviour (light-dark box), lick suppression (Vogel conflict), conditioned fear, and forced swimming.
Positive_regulation (overproducing) of corticotropin-releasing hormone associated with anxiety disorder
13) Confidence 0.49 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 0.96 Pain Relevance 0.11
Increasing central CRF levels (via icv injections) (which would presumably increase activation of CRFR1) decreases maternal responding in maternally sensitized virgin rats [6].
Positive_regulation (Increasing) of CRF
14) Confidence 0.47 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.46 Pain Relevance 0.08
The gel filtration analyses revealed that a higher molecular weight form of ir beta-EP, putative POMC, was increased in CRH KO, but the beta-EP peak level was small and similar between two groups.
Positive_regulation (increased) of CRH KO
15) Confidence 0.46 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15331153 Disease Relevance 0.16 Pain Relevance 0.08
Corticotrophin-releasing factor (CRF) and vasopressin (AVP) are key regulators of the stress response via activation of CRF(1) and V(1b) receptors, respectively.
Positive_regulation (activation) of CRF associated with stress
16) Confidence 0.46 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 0.79 Pain Relevance 0.31
Corticotrophin-releasing factor (CRF) and vasopressin (AVP) are key regulators of the stress response via activation of CRF(1) and V(1b) receptors, respectively.
Positive_regulation (activation) of Corticotrophin-releasing factor associated with stress
17) Confidence 0.46 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 0.79 Pain Relevance 0.26
The ethanol- and CRF-induced increase in GABAergic transmission is mediated by CRF1 receptor activation, but the intracellular signaling mechanisms involved in this alteration in GABA transmission are still unknown.
Positive_regulation (increase) of CRF-induced associated with gaba and gabaergic
18) Confidence 0.46 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.21 Pain Relevance 0.52
Using pharmacological and genetic approaches, we found that the anxiogenic-like effects of Corticotropin Releasing Factor (CRF) were triggered by CRF1-R activation of the dynorphin/kappa opioid receptor (KOR) system.
Positive_regulation (triggered) of CRF associated with dynorphin and kappa opioid receptor
19) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2795205 Disease Relevance 0.33 Pain Relevance 0.70
The cAMP-induced CRH promoter activity is reduced in the deletion construct which does not contain CRE.
Positive_regulation (induced) of CRH promoter
20) Confidence 0.41 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.19 Pain Relevance 0

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