INT211776

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.43
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA binding (PTBP2) mRNA processing (PTBP2) plasma membrane (PLVAP)
nucleus (PTBP2) cytoplasm (PLVAP)
Anatomy Link Frequency
SH-SY5Y 1
PTBP2 (Homo sapiens)
PLVAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 17 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
iatrogenic 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Sciatic nerve 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 98.54 Very High Very High Very High
Common Cold 4 72.64 Quite High
Syndrome 3 70.24 Quite High
Systemic Lupus Erythematosus 1 68.80 Quite High
Autoimmune Disease 1 67.88 Quite High
Polio 56 5.00 Very Low Very Low Very Low
Sprains And Strains 19 5.00 Very Low Very Low Very Low
Infection 16 5.00 Very Low Very Low Very Low
Paralysis 10 5.00 Very Low Very Low Very Low
Pox Virus Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An attenuating mutation, C472U, reduced the affinity of the PV 5'NTR to pPTB in neuroblastoma cells (SH-SY5Y) without disrupting this interaction in HeLa cells [74]. nPTB, a neuronal-cell specific homologue of PTB, was later described to bind less efficiently to the PV IRES in the presence of the C472U attenuating mutation [73].
nPTB Binding (bind) of PV IRES in SH-SY5Y associated with neuroblastoma
1) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1947962 Disease Relevance 0.43 Pain Relevance 0

General Comments

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